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Development of modern Chinese medicine guided by molecular compatibility theory
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-08-05 , DOI: 10.1016/j.jare.2024.08.005 Lifeng Luo 1 , Jieru Zhou 1 , Xiaonan Liu 1 , Yanyu Chen 1 , Xiao Du 1 , Lili Gao 2 , Yunting Sun 3 , Shuling Wang 4
中文翻译：
以分子相容性理论为指导的现代中医发展
中医 （TCM） 已获得全球关注，尤其是在屠呦呦教授因发现青蒿素治疗疟疾而获得诺贝尔奖之后。然而，中医背后的理论通常被认为是一个具有复杂成分和不明确结构和作用机制的“黑匣子”。这阻碍了中医在现代医学框架内的发展。
谢天教授团队提出的分子相容性理论，将中医与西医相结合，为中医现代化提供了可行的方向。有必要对这一理论进行总结和普及。本文旨在系统地介绍这一理论，以期为中医的发展提供一些新的思路。
根据分子相容性理论，通过将中医的多个活性分子有机结合可以达到预期的效果。这些中医分子化合物成分具体、机理精确、质量可控，符合现代医学的标准。分子相容性理论指导了抗肿瘤新药榄香烯乳剂的开发，也揭示了中药衍生的活性分子与其他中药、西药或生物材料之间的广泛相容性。这一发现开辟了潜在的基于中医的治疗选择。总之，分子相容性理论有望成为中医现代化的策略。
更新日期：2024-08-05
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-08-05 , DOI: 10.1016/j.jare.2024.08.005 Lifeng Luo 1 , Jieru Zhou 1 , Xiaonan Liu 1 , Yanyu Chen 1 , Xiao Du 1 , Lili Gao 2 , Yunting Sun 3 , Shuling Wang 4
Affiliation
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Background
Traditional Chinese Medicine (TCM) has gained global attention, particularly after Professor Youyou Tu was awarded the Nobel Prize for her discovery of artemisinin as a treatment for malaria. However, the theory behind TCM is often perceived as a “black-box” with complex components and an unclear structure and mechanism of action. This had hindered the development of TCM within the framework of modern medicine.Aim of review
The molecular compatibility theory proposed by Professor Tian Xie’s team integrates TCM with Western medicine in clinical practice, and provide a feasible direction for TCM modernization. It is necessary to summarize and popularize this theory. This review aims to systematically introduce this theory to provide some new insight for development of TCM.Key scientific concepts of review
According to the molecular compatibility theory, the desired effects can be achieved by organically combining multiple active molecules from TCM. These TCM molecular compounds have specific ingredients, precise mechanisms, and controllable quality that meet the standards of modern medicine. The molecular compatibility theory has guided the development of antitumor new drug elemene emulsions, and has also revealed extensive compatibility between TCM-derived active molecules and other TCM, Western medicine, or biomaterials. This discovery opens up potential TCM-based treatment options. In conclusion, the molecular compatibility theory holds promise as a strategy for modernizing TCM.中文翻译：
以分子相容性理论为指导的现代中医发展
背景
中医 （TCM） 已获得全球关注，尤其是在屠呦呦教授因发现青蒿素治疗疟疾而获得诺贝尔奖之后。然而，中医背后的理论通常被认为是一个具有复杂成分和不明确结构和作用机制的“黑匣子”。这阻碍了中医在现代医学框架内的发展。
综述目的
谢天教授团队提出的分子相容性理论，将中医与西医相结合，为中医现代化提供了可行的方向。有必要对这一理论进行总结和普及。本文旨在系统地介绍这一理论，以期为中医的发展提供一些新的思路。
综述的关键科学概念
根据分子相容性理论，通过将中医的多个活性分子有机结合可以达到预期的效果。这些中医分子化合物成分具体、机理精确、质量可控，符合现代医学的标准。分子相容性理论指导了抗肿瘤新药榄香烯乳剂的开发，也揭示了中药衍生的活性分子与其他中药、西药或生物材料之间的广泛相容性。这一发现开辟了潜在的基于中医的治疗选择。总之，分子相容性理论有望成为中医现代化的策略。
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