Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment,Journal of Advanced Research

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Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-08-05 , DOI: 10.1016/j.jare.2024.07.033
Tongzheng Chen ₁ , Wenbin Ma ₁ , Xin Wang ₁ , Qile Ye ₁ , Xintong Hou ₁ , Yiwei Wang ₁ , Chuanlu Jiang ₂ , Xiangqi Meng ₁ , Ying Sun ₁ , Jinquan Cai ₁

Affiliation

Background

With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical application of immunotherapy, the precise roles and characteristics of immune cell subtypes, how glioma induces subtype transformation of immune cells and its impact on glioma progression have yet to be understood.

Aim of the review

In this review, we comprehensively center on the four major immune cells within the glioma microenvironment, particularly neutrophils, macrophages, lymphocytes, myeloid-derived suppressor cells (MDSCs), and other significant immune cells. We discuss (1) immune cell subtype markers, (2) glioma-induced immune cell subtype transformation, (3) the mechanisms of each subtype influencing chemotherapy resistance, (4) therapies targeting immune cells, and (5) immune cell-associated single-cell sequencing. Eventually, we identified the characteristics of immune cell subtypes in glioma, comprehensively summarized the exact mechanism of glioma-induced immune cell subtype transformation, and concluded the progress of single-cell sequencing in exploring immune cell subtypes in glioma.

Key scientific concepts of review

In conclusion, we have analyzed the mechanism of chemotherapy resistance detailly, and have discovered prospective immunotherapy targets, excavating the potential of novel immunotherapies approach that synergistically combines radiotherapy, chemotherapy, and surgery, thereby paving the way for improved immunotherapeutic strategies against glioma and enhanced patient outcomes.

中文翻译：

神经胶质瘤微环境中免疫细胞异质性、肿瘤引发的亚型转化、耐药性、治疗和检测技术的见解

背景

随着对神经胶质瘤发展和免疫微环境的逐渐了解，已经发现了许多免疫细胞。尽管对免疫细胞功能的理解越来越深入，免疫疗法的临床应用也越来越广泛，但免疫细胞亚型的确切作用和特征、神经胶质瘤如何诱导免疫细胞的亚型转化及其对神经胶质瘤进展的影响仍未得到了解。

综述目的

在这篇综述中，我们全面关注胶质瘤微环境中的四种主要免疫细胞，特别是中性粒细胞、巨噬细胞、淋巴细胞、髓源性抑制细胞（MDSC）和其他重要的免疫细胞。我们讨论了（1）免疫细胞亚型标志物，（2）神经胶质瘤诱导的免疫细胞亚型转化，（3）每种亚型影响化疗耐药的机制，（4）靶向免疫细胞的疗法，以及（5）免疫细胞相关单细胞测序。最终，我们确定了胶质瘤中免疫细胞亚型的特点，全面总结了胶质瘤诱导免疫细胞亚型转化的确切机制，并总结了单细胞测序在探索胶质瘤免疫细胞亚型方面的进展。