Atrazine (ATRA) and ciprofloxacin (CPRO) are widely detected, persistent and co-existing aquatic pollutants. This study investigated effects of 14-day single and joint ATRA and CPRO exposure on juvenile . Standard bioassay methods were used to determine responses of oxidative stress, hepatic condition, and immunological biomarkers on days 7 and 14. Seven groups were used: Control, CPRO, CPRO, ATRA, ATRA, CPRO+ATRA, and CPRO+ATRA. The test substances caused decreased activity of superoxide dismutase, catalase, and glutathione peroxidase. Lipid peroxidation was elevated, especially in CPRO-ATRA mixtures. Serum aminotransferases (ALT, and AST), and alkaline phosphatase activity increased significantly. Total protein, albumin, total immunoglobulin, and respiratory burst decreased significantly. Therefore, single and joint exposure to CPRO and ATRA poses adverse consequences on aquatic life.

中文翻译：

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单一和混合暴露于莠去津和环丙沙星对Clarias gariepinus抗氧化防御状态、肝脏状况和免疫反应的影响


阿特拉津 (ATRA) 和环丙沙星 (CPRO) 是广泛检测、持久且共存的水生污染物。本研究调查了 14 天单独和联合 ATRA 和 CPRO 暴露对青少年的影响。使用标准生物测定方法确定第 7 天和第 14 天的氧化应激、肝脏状况和免疫生物标志物的反应。使用七组：对照、CPRO、CPRO、ATRA、ATRA、CPRO+ATRA 和 CPRO+ATRA。受试物质导致超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性降低。脂质过氧化作用升高，尤其是在 CPRO-ATRA 混合物中。血清转氨酶（ALT和AST）和碱性磷酸酶活性显着增加。总蛋白、白蛋白、总免疫球蛋白和呼吸爆发显着下降。因此，单独或联合接触 CPRO 和 ATRA 会对水生生物造成不利影响。