is an economically important pest in agriculture, forestry, and construction. Recent studies have shown an increase in research focusing on the anti-termite properties of plant essential oils, however, there remains a lack of information regarding the specific molecular mechanism involved. In this study, RNA-seq analysis was conducted on termites exposed to essential oil (EO) and carvone, leading to the discovery of various genes that were expressed differentially under different treatment conditions. Numerous genes that exhibited a response to EO and carvone found to be associated with stress-related pathways, such as drug metabolism cytochrome P450, glutathione metabolism, fatty acid metabolism, citric acid cycle, neuroactive ligand-receptor interaction, cell apoptosis, the AMPK signalling pathway, the mTOR signalling pathway, the longevity regulation pathway, ubiquitin-mediated protein hydrolysis, and the calcium signalling pathway. The up-regulation of genes (SPHK) associated with calcium channels, such as SPHK, indicates a potential mechanism of neurotoxicity, while the up-regulation of apoptosis-associated genes, including ACTB_G1, PYG, SQSTM1, RNF31, suggests a potential mechanism of cytotoxicity. The metabolism of EO induces oxidative stress, elevates free Ca levels in mitochondria, and initiates the generation of reactive oxygen species (ROS), ultimately resulting in programmed cell necrosis and apoptosis, as well as facilitating cellular autophagy. The monoterpenes exhibited neurotoxic and cytotoxic effects on and could be exploited to advance termiticide development and eco-friendly termite control.

中文翻译：

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暴露于薄荷精油和香芹酮的黄胸散白蚁的转录组分析表明潜在的神经毒性作用机制，其特征是多巴胺受体介导的细胞内钙流入


是农业、林业和建筑业中重要的经济害虫。最近的研究表明，越来越多的研究集中在植物精油的抗白蚁特性上，然而，仍然缺乏有关具体分子机制的信息。在这项研究中，对暴露于精油（EO）和香芹酮的白蚁进行了RNA-seq分析，发现了在不同处理条件下表达差异的多种基因。许多对 EO 和香芹酮表现出反应的基因被发现与应激相关途径相关，例如药物代谢细胞色素 P450、谷胱甘肽代谢、脂肪酸代谢、柠檬酸循环、神经活性配体-受体相互作用、细胞凋亡、AMPK 信号传导途径、mTOR信号途径、寿命调节途径、泛素介导的蛋白质水解和钙信号途径。与钙通道相关的基因（SPHK）的上调，如SPHK，表明了神经毒性的潜在机制，而凋亡相关基因，包括ACTB_G1、PYG、SQSTM1、RNF31的上调，表明了潜在的神经毒性机制。细胞毒性。 EO 的代谢会引起氧化应激，提高线粒体中的游离 Ca 水平，并引发活性氧 (ROS) 的产生，最终导致程序性细胞坏死和凋亡，并促进细胞自噬。单萜表现出神经毒性和细胞毒性作用，可用于促进杀白蚁剂的开发和生态友好的白蚁控制。