Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity,Journal of Natural Products

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Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
Journal of Natural Products ( IF 3.3 ) Pub Date : 2024-08-09 , DOI: 10.1021/acs.jnatprod.4c00577
Anita Barta _{1,

2} , Agostina Salusso ₃ , Norbert Kúsz ₁ , Róbert Berkecz ₄ , Jan Schlauer ₅ , Dragica Purger ₆ , Judit Hohmann _{1,

2} , Maria Cecilia Carpinella ₃ , Andrea Vasas _{1,

2}

Affiliation

Continuing our search for bioactive compounds in species from the Juncaceae family, Juncus articulatus was investigated. Ten previously undescribed phenanthrenes─articulins A–J (1–10)─and ten known compounds─juncuenin B, dehydrojuncuenin B, juncatrin B, ensifolins E, F, H, I, K, juncuenin D, and luzulin A (11–20)─along with other compounds, have been isolated and identified. The isolated compounds were evaluated for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA). Compounds 12 and 14 exhibited the most potent activity against planktonic and sessile MSSA and MRSA with minimum inhibitory concentration (MIC) values of 15.1 μM (12 for both bacterial strains) and 15.3 μM (14 for both bacterial strains). Compounds 15, 17, and 18 also exhibited activity against both strains, although to a lower extent, with MIC values ranging from 30.0 to 56.8 μM. The inhibition of biofilm formation of these compounds was observed at 15.1–114.3 μM. This study elucidates the phenanthrene composition of J. articulatus and the antibacterial effect of these compounds.

中文翻译：

灯心灯心草中的菲具有抗菌和生物膜形成抑制活性

我们继续在灯芯草科物种中寻找生物活性化合物，并对灯心草进行了研究。十种先前未描述的菲─articulins A–J ( 1 – 10 )─以及十种已知化合物─juncuenin B、脱氢juncuenin B、juncatrin B、ensifolins E、F、H、I、K、juncuenin D 和 luzulin A ( 11 – 20 ）──与其他化合物一起已被分离和鉴定。评估了分离的化合物对大肠杆菌、铜绿假单胞菌、甲氧西林敏感金黄色葡萄球菌(MSSA) 和耐甲氧西林金黄色葡萄球菌(MRSA) 的抗菌活性。化合物12和14对浮游和固着 MSSA 和 MRSA 表现出最有效的活性，最低抑制浓度 (MIC) 值为 15.1 μM（两种细菌菌株为12 ）和 15.3 μM（两种细菌菌株为14 ）。化合物15、17和18也表现出针对两种菌株的活性，尽管程度较低，MIC值范围为30.0至56.8μM。在 15.1–114.3 μM 浓度下观察到这些化合物对生物膜形成的抑制作用。这项研究阐明了J. articulatus的菲成分以及这些化合物的抗菌作用。

更新日期：2024-08-09

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