Introduction Delirium and multiple long-term conditions (MLTC) share numerous risk factors and have been shown individually to be associated with adverse outcomes following hospitalisation. However, the extent to which these common ageing syndromes have been studied together is unknown. This scoping review aims to summarise our knowledge to date on the interrelationship between MLTC and delirium. Methods Searches including terms for delirium and MLTC in adult human participants were performed in PubMed, EMBASE, Medline, Psycinfo and CINAHL. Descriptive analysis was used to summarise findings, structured according to Synthesis Without Meta-analysis reporting guidelines. Results After removing duplicates, 5256 abstracts were screened for eligibility, with 313 full-texts sought along with 17 additional full-texts from references in review articles. 151 met inclusion criteria and were included in the final review. Much of the literature focusing on hospitalised participants (n = 140) explored MLTC as a risk factor for delirium (n = 125). Fewer studies explored the impact of MLTC on delirium presentation (n = 5), duration (n = 3) or outcomes (n = 6) and no studies explored how MLTC impacts the treatment of delirium or whether having delirium increases risk of developing MLTC. The most frequently used measures of MLTC and delirium were the Charlson Comorbidity Index (n = 107/151) and Confusion Assessment Method (n = 88/151), respectively. Conclusion Existing literature largely evaluates MLTC as a risk factor for delirium. Major knowledge gaps identified include the impact of MLTC on delirium treatment and the effect of delirium on MLTC trajectories. Current research in this field is limited by significant heterogeneity in defining both MLTC and delirium.

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2318 多种长期疾病 （MLTC） 与谵妄之间的相互关系：范围综述


简介 谵妄和多种长期疾病 （MLTC） 有许多共同的危险因素，并且已单独显示与住院后的不良结局相关。然而，这些常见衰老综合征被一起研究的程度尚不清楚。本范围综述旨在总结我们迄今为止关于 MLTC 和谵妄之间相互关系的知识。方法 在 PubMed 、 EMBASE 、 Medline 、 Psycinfo 和 CINAHL 中进行检索，包括成人人类参与者的谵妄和 MLTC 术语。描述性分析用于总结结果，根据 Synthesis Without Meta 分析报告指南进行结构化。结果 删除重复项后，筛选了 5256 篇摘要的合格性，其中 313 篇全文以及 17 篇来自综述文章的参考文献的补充全文。151 例符合纳入标准并被纳入最终评价。许多关注住院参与者的文献 （n = 140） 将 MLTC 作为谵妄的危险因素 （n = 125）。较少的研究探讨了 MLTC 对谵妄表现 （n = 5）、持续时间 （n = 3） 或结局 （n = 6） 的影响，也没有研究探讨 MLTC 如何影响谵妄的治疗或谵妄是否会增加患 MLTC 的风险。最常用的 MLTC 和谵妄测量分别是 Charlson 合并症指数 （n = 107/151） 和混淆评估方法 （n = 88/151）。结论 现有文献主要将 MLTC 评估为谵妄的危险因素。确定的主要知识差距包括 MLTC 对谵妄治疗的影响以及谵妄对 MLTC 轨迹的影响。该领域的当前研究受到定义 MLTC 和谵妄的显着异质性的限制。