Introduction Pulmonary hypertension evaluated by echocardiography and ROX index in older patients with COVID-19 could be linked to worse outcomes. Methods We conducted a retrospective cohort of adult patients with COVID-19. The main objective was to evaluate pulmonary hypertension as an echocardiographic finding and its association with hard outcomes in patients with COVID-19 infection. In the inferential statistical analysis, the OR with confidence intervals greater than 95% was used as a measure of association. Qualitative variables were evaluated using the Chi square test or Fisher’s exact test. In quantitative variables, the Student’s T test, or Mann–Whitney test, was used. Results 306 individuals with COVID-19 infection were included; the majority of these were men (78% vs. 22% women). Patients who died had lower ROX values at 2 hours compared to survivors (4,5 with a SD of 3,6–5,6, vs. 5,8 with a SD of 4,7–6,1, respectively). This trend was maintained at 12 hours (4,9 with a SD of 3,8–6,0 for deceased patients vs. 7,8 with a SD of 5,2–8,7 for survivors). For the ROX index at 2 hours, an OR adjusted for age and gender of 8,5 with a CI of 2,0–91,4 was found, and at 12 hours, an OR of 17,6 with a CI of 2,8–93,6 was found. Low values of the ROX index were associated with pulmonary hypertension (p = 0.048) and higher mortality (p = 0.037). Conclusions In patients with COVID-19, the presence of pulmonary hypertension estimated by ecocardiography and the ROX index is associated with worse outcomes, including a higher rate of comorbidities and mortality in patients over 70 years of age. Prospective studies with a more representative population sample are required to validate the results found here.

中文翻译：

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2146 拉丁美洲队列老年病学SARSCOV2患者超声心动图肺动脉高压评估


简介 通过超声心动图和 ROX 指数评估老年 COVID-19 患者的肺动脉高压可能与较差的结果有关。方法 我们对成年 COVID-19 患者进行了回顾性队列分析。主要目的是评估肺动脉高压作为超声心动图发现及其与 COVID-19 感染患者困难结局的关系。在推理统计分析中，置信区间大于 95% 的 OR 被用作相关性的衡量标准。使用卡方检验或 Fisher 精确检验评估定性变量。在定量变量中，使用了 Student's T 检验或 Mann-Whitney 检验。结果 共纳入 306 例 COVID-19 感染者;其中大多数是男性（78% 对 22% 女性）。与幸存者相比，死亡患者在 2 小时时的 ROX 值较低（4,5 例 SD 为 3,6-5,6,5,8 例 SD 为 4,7-6,1）。这一趋势维持在 12 小时（已故患者 4,9 的 SD 为 3,8-6,0，而幸存者的 7,8 的 SD 为 5,2-8,7）。对于 2 小时时的 ROX 指数，发现根据年龄和性别调整的 OR 为 8,5，CI 为 2,0-91,4,12 小时时，OR 为 17,6，CI 为 2,8-93,6。ROX 指数的低值与肺动脉高压 （p = 0.048） 和较高的死亡率 （p = 0.037） 相关。结论 在 COVID-19 患者中，通过生态心电图和 ROX 指数估计的肺动脉高压的存在与较差的结局相关，包括 70 岁以上患者的合并症发生率和死亡率较高。需要具有更具代表性的人群样本的前瞻性研究来验证此处找到的结果。