Four hundred and eighty newly weaned pigs (PIC 337 × 1050; Genus, Hendersonville, TN) with an initial body weight (BW) of 6.20 ± 0.61 kg were used in a dose-response study to investigate the impact of increasing standardized ileal digestible (SID) Arg:Lys on nursery pig growth performance. At weaning, pigs were placed into 48 pens with five barrows and five gilts per pen. Pens were randomly assigned to one of six dietary treatments. The experimental diets were formulated with increasing SID Arg:Lys, achieved by substituting corn starch, glycine, and L-alanine with L-arginine, resulting in SID Arg:Lys ranging from 45 to 145%. Diets were sub-limiting in SID Lys and exceeded all other essential amino acid requirements. The experimental diets were fed across two feeding phases from d 0 to 10 and 10 to 27, with adjustments made to account for the Lys requirement of the pigs. All pens were placed on a common diet for the remaining 14 days of the study to evaluate carryover effects. Pigs and feeders were weighed at the start and end of each phase to calculate average daily gain (ADG), average daily feed intake (ADFI), and feed efficiency (G:F). Data were analyzed according to a linear regression model, which included the linear and quadratic effects of SID Arg:Lys and initial BW. Pen was the experimental unit, and results were considered significant at P ≤ 0.05 and a tendency at 0.50 < P ≤ 0.10. From d 0 to 27, Arg:Lys tended to have a quadratic effect on ADFI (P = 0.058), where 97.00 ± 7.631% SID Arg:Lys maximized feed intake. Similarly, Arg:Lys had a quadratic impact on ADG (P = 0.046), where ADG was maximized at a SID Arg:Lys of 95.65 ± 7.165. Correspondingly, Arg:Lys had a quadratic effect on pig BW on d 27 (P = 0.014). These effects carried through the end of the study, where Arg:Lys quadratically impacted d 0 to 41 ADFI (P = 0.006), ADG (P = 0.077), and d 41 BW (P = 0.028). There was no evidence of an effect of SID Arg:Lys on G:F throughout the study (P ≥ 0.315). In conclusion, SID Arg:Lys quadratically impacted ADFI and ADG in 6 to 13 kg nursery pigs, where ADFI was maximized at a SID Arg:Lys of 97.00% (95% CI [81.6, 112.4%]), and ADG was maximized at a SID Arg:Lys of 95.65% (95% CI [81.2, 110.1%]). Together, these data suggest that the SID Arg:Lys requirement of nursery pigs is at least 81%, based on the lower bounds of the 95% CI for maximum ADG and ADFI, and excessive Arg supplementation may negatively affect growth performance.

中文翻译：

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标准化回肠可消化精氨酸：赖氨酸对 6 至 13 kg 保育猪生长性能的影响


480 头新断奶仔猪（PIC 337 × 1050;初始体重 （BW） 为 6.20 ± 0.61 kg 的属，田纳西州亨德森维尔）用于剂量反应研究，以研究增加标准化回肠可消化 （SID） Arg：Lys 对保育猪生长性能的影响。断奶时，将猪放入 48 个猪栏，每个猪栏 5 个栏和 5 个后备母猪。笔被随机分配到六种饮食处理中的一种。通过用 L-精氨酸代替玉米淀粉、甘氨酸和 L-丙氨酸，使实验日粮增加 SID Arg：Lys，导致 SID Arg：Lys 在 45% 到 145% 之间。饮食在 SID Lys 中是次限制的，超过了所有其他必需氨基酸的需求。实验日粮在第 0 至 10 天和第 10 天至第 27 天的两个饲喂阶段进行饲喂，并根据猪的 Lys 需求进行调整。在研究的剩余 14 天内，所有笔都采用普通饮食，以评估残留效应。在每个阶段的开始和结束时对猪和喂食器进行称重，以计算平均日增重 （ADG）、平均日采食量 （ADFI） 和饲料效率 （G：F）。根据线性回归模型分析数据，其中包括 SID Arg：Lys 和初始 BW 的线性和二次效应。Pen 是实验单位，在 P ≤ 0.05 时，结果被认为显著，在 0.50 < P ≤ 0.10 时有趋势。从第 0 天到第 27 天，Arg：Lys 对 ADFI 趋于二次效应 （P = 0.058），其中 97.00 ± 7.631% SID Arg：Lys 使采食量最大化。同样，Arg：Lys 对 ADG 有二次影响 （P = 0.046），其中 ADG 在 SID Arg：Lys 为 95.65 ± 7.165 时最大化。相应地，Arg：Lys 对第 27 天猪 BW 具有二次效应 （P = 0.014）。 这些影响一直持续到研究结束时，其中 Arg：Lys 对 d 0 至 41 ADFI （P = 0.006） 、 ADG （P = 0.077） 和 d 41 BW （P = 0.028） 产生二次影响。在整个研究过程中，没有证据表明 SID Arg：Lys 对 G：F 有影响 （P ≥ 0.315）。总之，SID Arg：Lys对6至13 kg保育猪的ADFI和ADG产生二次影响，其中ADFI在SID Arg：Lys为97.00%（95% CI [81.6， 112.4%]）时最大，ADG在SID Arg：Lys为95.65%（95% CI [81.2， 110.1%]）时最大。综上所述，这些数据表明，根据最大 ADG 和 ADFI 的 95% 置信区间的下限，保育猪的 SID Arg：Lys 需求量至少为 81%，过量补充 Arg 可能会对生长性能产生负面影响。