We performed single-nucleus chromatin accessibility mapping and RNA sequencing of breast biopsy samples obtained from healthy donors of diverse genetic ancestry and present a comprehensive single-nucleus atlas that describes specific markers of major cell types of the breast. Gene expression and signaling differences between ductal and lobular epithelial cells are also described.

中文翻译：

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健康乳房染色质可及性和转录组的详细映射


我们对从不同遗传血统的健康供体获得的乳腺活检样本进行了单核染色质可及性映射和 RNA 测序，并提出了一个全面的单核图谱，描述了乳腺主要细胞类型的特异性标志物。还描述了导管和小叶上皮细胞之间的基因表达和信号传导差异。