Obesity increases osteoarthritis (OA) risk due to adipose tissue dysfunction with associated metabolic syndrome and excess weight. Lipodystrophy syndromes exhibit systemic metabolic and inflammatory abnormalities similar to obesity without biomechanical overloading. Here, we used lipodystrophy mouse models to investigate the effects of systemic versus intra-articular adipose tissue dysfunction on the knee.

中文翻译：

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解开局部和全身性脂肪组织功能障碍对膝关节软骨的有害影响


肥胖会增加骨关节炎 （OA） 的风险，因为脂肪组织功能障碍伴有相关的代谢综合征和超重。脂肪代谢障碍综合征表现出类似于肥胖的全身代谢和炎症异常，但无生物力学超负荷。在这里，我们使用脂肪代谢障碍小鼠模型来研究全身性与关节内脂肪组织功能障碍对膝关节的影响。