Interleukin receptor therapeutics attenuate inflammation in canine synovium following cruciate ligament injury,Osteoarthritis and Cartilage

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Interleukin receptor therapeutics attenuate inflammation in canine synovium following cruciate ligament injury
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2024-07-14 , DOI: 10.1016/j.joca.2024.06.010
Elisabeth A Lemmon ₁ , Kevin G Burt ₂ , Sung Yeon Kim ₁ , Bryan Kwok ₃ , Lorielle Laforest ₁ , Rui Xiao ₄ , Lin Han ₃ , Carla R Scanzello ₅ , Robert L Mauck ₁ , Kimberly A Agnello ₆

Affiliation

Translational Musculoskeletal Research Center, CMC VA Medical Center, Philadelphia, PA, United States; McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States.
Translational Musculoskeletal Research Center, CMC VA Medical Center, Philadelphia, PA, United States; McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States.
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Pediatrics Division of Biostatistics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Translational Musculoskeletal Research Center, CMC VA Medical Center, Philadelphia, PA, United States; Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, United States.

In the knee, synovial fibrosis after ligamentous injury is linked to progressive joint pain and stiffness. The objective of this study was to evaluate changes in synovial architecture, mechanical properties, and transcriptional profiles following naturally occurring cruciate ligament injury in canines and to test potential therapeutics that target drivers of synovial inflammation and fibrosis.

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