<br>苯并（a）芘/苯并（a）芘-7,8-二氢二醇-9,10-环氧化物对DNA甲基化的双重影响,Science of the Total Environment

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苯并（a）芘/苯并（a）芘-7,8-二氢二醇-9,10-环氧化物对DNA甲基化的双重影响
Science of the Total Environment ( IF 8.2 ) Pub Date : 2024-07-29 , DOI: 10.1016/j.scitotenv.2024.175042
Cheng Zhao ₁ , Hui Jin ₂ , Yu Lei ₁ , Qilin Li ₁ , Ying Zhang ₃ , Qianjin Lu ₄

Affiliation

Department of Dermatology, The Second Xiangya Hospital of Central South University, Central South University Hunan Key Laboratory of Medical Epigenomics Changsha, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences Institute of Dermatology, Nanjing, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China; Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha, China.
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China.
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Department of Dermatology, The Second Xiangya Hospital of Central South University, Central South University Hunan Key Laboratory of Medical Epigenomics Changsha, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences Institute of Dermatology, Nanjing, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China.

苯并（a）芘（BaP）是研究最深入的多环芳烃（PAH）之一，是人类生活各个领域广泛存在的有机污染物。其对生物体的致畸、免疫毒性和致癌作用已得到充分证明，并得到研究人员的广泛认可。在体内，苯并芘被酶促转化为更具活性的苯并（a）芘-7,8-二氢二醇-9,10-环氧化物（BPDE）。BaP/BPDE 有可能触发基因突变，影响表观遗传修饰并导致细胞结构损伤，最终导致疾病发作和进展。然而，在使用 BaP/BPDE 研究表观遗传学时，存在不同的观点。一方面，癌症研究中声称 BaP/BPDE 有助于基因高甲基化，特别是诱导肿瘤抑制基因启动子的高甲基化，导致基因沉默和随后的癌症发展。相反，对人类和动物群体的研究表明，暴露于 BaP 会导致全基因组 DNA 低甲基化，可能导致炎症性疾病的不良后果。近四十年来，这一明显的矛盾一直没有在研究中得到总结。

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更新日期：2024-07-29

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