Endoscopic full-thickness suturing has multiple potential therapeutic applications, including bariatric procedures and gastrointestinal (GI) wall defect closure; previous suturing devices have been complex or of unknown or limited efficacy. We present animal results of a new device (the Su2ura GI) used through one instrumentation channel of a conventional endoscope with a 3.2 mm channel. Six animal experiments were performed, and animals did well on follow-up; two animals surviving for 28 days were histologically examined, showing the creation of full-thickness sutures using the Su2ura GI device. This device should be tested further in clinical trials. In recent years, endoscopic full-thickness suturing has been increasingly used for various procedures, including the treatment of GI perforations, fistulas and anastomotic leaks, closure of full-thickness defects in the GI wall following endoscopic mucosal resection or endoscopic submucosal dissection, fixation of intraluminal stents and gastric remodelling techniques for treating obesity.1–3 Current full-thickness suturing devices are complex to use, requiring advanced technical skills and significant experience or have unknown or limited efficacy.3–7 The need for an easy-to-use, through-the-scope and versatile endoscopic suturing device is unmet. We present a new through-the-scope device (the Su2ura GI device) designed for full-thickness sutures in the upper and lower GI tract, with several potential applications and minimal training. The sutures are deployed in a simple, intuitive dual-trigger and semiautomatic operation requiring minimal training in endoscopic suites. The Su2ura GI device is an endoscopic, non-surgical instrument designed to suture through an endoscope channel in both the upper and lower GI tract. The Su2ura GI device is a universal suturing platform that comprises mechanisms for multiple full-thickness T-tag sutures deployment, approximation, re-tightening as needed and thread locking and cutting. It can be affixed to any endoscope with an operative channel of at least 3.2 mm. The device follows the direction of the endoscope. The …

中文翻译：

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新型全层内窥镜缝合装置的动物实验


内窥镜全层缝合具有多种潜在的治疗应用，包括减肥手术和胃肠道 （GI） 壁缺损闭合;以前的缝合装置很复杂或疗效未知或有限。我们介绍了一种新设备 （Su2ura GI） 的动物结果，该设备通过具有 3.2 毫米通道的常规内窥镜的一个器械通道使用。进行了 6 次动物实验，动物随访情况良好;对两只存活 28 天的动物进行了组织学检查，显示使用 Su2ura GI 设备创建了全层缝合线。该设备应在临床试验中进一步测试。近年来，内窥镜全层缝合越来越多地用于各种手术，包括胃肠道穿孔、瘘管和吻合口瘘的治疗、内窥镜粘膜切除术或内窥镜粘膜下剥离后胃肠道壁全层缺损的闭合、腔内支架的固定和治疗肥胖的胃重塑技术。 需要高级技术技能和丰富经验或疗效未知或有限.3-7 对易于使用、通过范围和多功能的内窥镜缝合装置的需求尚未得到满足。我们提出了一种新的通过范围装置 （Su2ura GI 装置），专为上下消化道的全层缝合而设计，具有多种潜在应用和最少的培训。缝合线以简单、直观的双触发和半自动操作方式部署，只需在内窥镜室中进行最少的培训。Su2ura GI 装置是一种内窥镜非手术器械，旨在通过上下胃肠道的内窥镜通道缝合。 Su2ura GI 装置是一种通用缝合平台，包括用于多个全层 T 标签缝合展开、近似、根据需要重新拧紧以及螺纹锁定和切割的机构。它可以贴在任何手术通道至少为 3.2 毫米的内窥镜上。该设备跟随内窥镜的方向。这。。。