Disentangling clinical and biological trajectories of neurodegenerative diseases,Nature Reviews Neurology

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Disentangling clinical and biological trajectories of neurodegenerative diseases
Nature Reviews Neurology ( IF 28.2 ) Pub Date : 2024-08-08 , DOI: 10.1038/s41582-024-01004-3
Nicolas Villain _{1,

2} , Vincent Planche _{3,

4}

Affiliation

In recent years, we have seen a shift towards defining sporadic neurodegenerative diseases as a biological continuum. Here, we discuss the risks associated with this shift, emphasize the importance of maintaining a strong connection between disease definitions and subsequent clinical outcomes, and suggest clinicobiological frameworks to disentangle multiple discrete nosological entities.

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