Photoclick reactions combine the advantages offered by light-driven processes, that is, non-invasive and high spatiotemporal control, with classical click chemistry and have found applications ranging from surface functionalization, polymer conjugation, photocrosslinking, protein labelling and bioimaging. Despite these advances, most photoclick reactions typically require near-ultraviolet (UV) and mid-UV light to proceed. UV light can trigger undesirable responses, including cellular apoptosis, and therefore, visible and near-infrared light-induced photoclick reaction systems are highly desirable. Shifting to a longer wavelength can also reduce degradation of the photoclick reagents and products. Several strategies have been used to induce a bathochromic shift in the wavelength of irradiation-initiating photoclick reactions. For instance, the extension of the conjugated π-system, triplet–triplet energy transfer, multi-photon excitation, upconversion technology, photocatalytic and photoinitiation approaches, and designs involving photocages have all been used to achieve this goal. Current design strategies, recent advances and the outlook for long wavelength-driven photoclick reactions are presented.

光点击反应将光驱动过程的优点（即非侵入性和高时空控制）与经典点击化学相结合，并已在表面功能化、聚合物共轭、光交联、蛋白质标记和生物成像等领域得到应用。尽管取得了这些进步，大多数光点击反应通常需要近紫外 (UV) 和中紫外光才能进行。紫外线会引发不良反应，包括细胞凋亡，因此，非常需要可见光和近红外光诱导的光点击反应系统。转向更长的波长还可以减少光点击试剂和产品的降解。已使用多种策略来诱导辐射引发的光点击反应的波长发生红移。例如，共轭π系统的扩展、三重态-三重态能量转移、多光子激发、上转换技术、光催化和光引发方法以及涉及光笼的设计都已被用来实现这一目标。介绍了长波长驱动光点击反应的当前设计策略、最新进展和前景。