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Serum levels of B-cell activating factor are associated with a reduced risk of chronic lymphocytic leukemia
Blood Cancer Journal ( IF 12.9 ) Pub Date : 2024-08-07 , DOI: 10.1038/s41408-024-01106-7 Eleanor Frost 1 , Jonathan N Hofmann 2 , Wen-Yi Huang 2 , Ashley A Frazer-Abel 3 , Kevin D Deane 3 , Sonja I Berndt 2
中文翻译：
血清 B 细胞活化因子水平与慢性淋巴细胞白血病风险降低相关
更新日期：2024-08-08
Blood Cancer Journal ( IF 12.9 ) Pub Date : 2024-08-07 , DOI: 10.1038/s41408-024-01106-7 Eleanor Frost 1 , Jonathan N Hofmann 2 , Wen-Yi Huang 2 , Ashley A Frazer-Abel 3 , Kevin D Deane 3 , Sonja I Berndt 2
Affiliation
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Immune dysregulation is thought to contribute to chronic lymphocytic leukemia (CLL) risk, but biological mechanisms are unclear. We discovered that increased serum levels of B-cell activating factor (BAFF), an important regulator of B-cell maturation, were associated with a decreased risk of CLL, even >10 years after blood draw. Our findings suggest that BAFF could be a useful biomarker to assess risk among individuals at high risk, such as those with monoclonal b-cell lymphocytosis.
中文翻译：
血清 B 细胞活化因子水平与慢性淋巴细胞白血病风险降低相关
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免疫失调被认为会导致慢性淋巴细胞白血病 （CLL） 风险，但生物学机制尚不清楚。我们发现 B 细胞活化因子 （BAFF） 是 B 细胞成熟的重要调节因子，血清水平升高与 CLL 风险降低有关，即使在抽血后 >10 年也是如此。我们的研究结果表明，BAFF 可能是一种有用的生物标志物，用于评估高危个体的风险，例如单克隆 B 细胞淋巴细胞增多症患者。
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