BackgroundThe consequences of drug allergy remain a global health concern. Drug allergy is often a neglected topic and many non‐specialists lack sufficient knowledge or confidence in evaluating or managing this common condition. Evidence‐based interventions to better equip non‐specialists to tackle drug allergy are needed. The aim of the study is to evaluate the effectiveness of an intensive educational course on drug allergy knowledge and practice of non‐specialists.MethodsA randomized crossover trial (NCT06399601) was conducted among practicing physicians and nurses participating in an intensive drug allergy course—Advances in Drug Allergy & Penicillin Testing (ADAPT). Participants' baseline knowledge and self‐reported practices were assessed with standardized questionnaires (scored from 0 to 100, with “satisfactory” defined as ≥60/100). Participants were randomized into two cohorts and attended ADAPT at different time points. Serial responses before and after the course were compared within and between cohorts.ResultsSeventy participants (25 physicians, 45 nurses) randomized into two groups completed the course. Baseline drug allergy knowledge (58.0 ± 19.9) and self‐reported practice (36.9 ± 24.3) were unsatisfactory among non‐specialists, with significantly lower scores from nurses than physicians in both domains (knowledge: 49.0 ± 17.4 vs. 74.0 ± 12.7; practice: 32.1 ± 21.3 vs. 53.3 ± 23.1; all p < 0.001).Following completion of ADAPT, participants demonstrated significant improvements in knowledge (58.0 ± 19.9 vs. 77.7 ± 15.9, p < 0.001) and self‐reported practice (36.9 ± 24.3 vs. 71.0 ± 20.2, p < 0.001). All participants (100%) and 99% of participants agreed that the course improved their clinical knowledge and practice, respectively.ConclusionsADAPT, an intensive drug allergy educational course was effective in improving drug allergy knowledge and practice for non‐specialists. Further longitudinal studies are required to evaluate long‐term impact.

中文翻译：

---

药物过敏教育课程对非专业人士的影响：ADAPT 的结果——一项随机交叉试验


背景药物过敏的后果仍然是全球健康问题。药物过敏往往是一个被忽视的话题，许多非专业人士缺乏足够的知识或信心来评估或管理这种常见病症。需要基于证据的干预措施，以更好地装备非专家来解决药物过敏问题。本研究的目的是评估非专业人士药物过敏知识和实践强化教育课程的有效性。方法在参加药物过敏强化课程的执业医师和护士中进行了一项随机交叉试验（NCT06399601）——进展药物过敏和青霉素测试 (ADAPT)。通过标准化问卷评估参与者的基线知识和自我报告的实践（评分从0到100，“满意”定义为≥60/100）。参与者被随机分为两组，并在不同时间点参加 ADAPT。比较了队列内和队列之间的课程前后的系列反应。结果 70 名参与者（25 名医生，45 名护士）随机分为两组，完成了课程。非专业人士的基线药物过敏知识 (58.0 ± 19.9) 和自我报告的实践 (36.9 ± 24.3) 均不能令人满意，护士在这两个领域的得分均显着低于医生（知识：49.0 ± 17.4 vs. 74.0 ± 12.7；实践） ：32.1 ± 21.3 对比 53.3 ± 23.1；全部p < 0.001)。完成 ADAPT 后，参与者表现出知识的显着提高（58.0 ± 19.9 vs. 77.7 ± 15.9， p < 0.001）和自我报告的实践（36.9 ± 24.3 vs. 71.0 ± 20.2， p < 0.001)。 所有参与者 (100%) 和 99% 的参与者分别同意该课程提高了他们的临床知识和实践。结论 ADAPT，强化药物过敏教育课程，可有效提高非专业人员的药物过敏知识和实践。需要进一步的纵向研究来评估长期影响。