Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants,Advanced Healthcare Materials

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Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2024-08-07 , DOI: 10.1002/adhm.202402373
Yilan Xu _{1,

2} , Honglu Lin ₁ , Boyang Xiao _{1,

2} , Hutomo Tanoto ₃ , Joel Berinstein ₄ , Alend Khoshnaw ₄ , Simon Young ₅ , Yuxiao Zhou ₃ , Xiaoguang Dong _{1,

2,

4}

Affiliation

Enabling minimally invasive and precise control of liquid release in dental implants is crucial for therapeutic functions such as delivering antibiotics to prevent biofilm formation, infusing stem cells to promote osseointegration, and administering other biomedicines. However, achieving controllable liquid cargo release in dental implants remains challenging due to the lack of wireless and miniaturized fluidic control mechanisms. Here wireless miniature pumps and valves that allow remote activation of liquid cargo delivery in dental implants, actuated and controlled by external magnetic fields (<65 mT), are reported. A magnet-screw mechanism in a fluidic channel to function as a piston pump, alongside a flexible magnetic valve designed to open and close the fluidic channel, is proposed. The mechanisms are showcased by storing and releasing of liquid up to 52 µL in a dental implant. The liquid cargos are delivered directly to the implant–bone interface, a region traditionally difficult to access. On-demand liquid delivery is further showed by a metal implant inside both dental phantoms and porcine jawbones. The mechanisms are promising for controllable liquid release after implant placement with minimal invasion, paving the way for implantable devices that enable long-term and targeted delivery of therapeutic agents in various bioengineering applications.

中文翻译：

用于牙种植体中受控液体输送的无线驱动微流体泵和阀门

实现牙种植体中液体释放的微创和精确控制对于治疗功能至关重要，例如输送抗生素以防止生物膜形成、注入干细胞以促进骨整合以及施用其他生物药物。然而，由于缺乏无线和小型化流体控制机制，在牙种植体中实现可控液体货物释放仍然具有挑战性。这里报道了无线微型泵和阀门，它们允许远程激活牙科植入物中的液体货物输送，并由外部磁场 (<65 mT) 驱动和控制。提出了一种在流体通道中充当活塞泵的磁力螺杆机构，以及设计用于打开和关闭流体通道的柔性电磁阀。通过在牙种植体中储存和释放高达 52 µL 的液体来展示该机制。液体货物直接输送到植入物-骨界面，这是传统上难以到达的区域。牙科模型和猪颌骨内的金属植入物进一步显示了按需液体输送。该机制有望在植入物植入后以最小的侵入实现可控的液体释放，为可植入装置铺平道路，从而能够在各种生物工程应用中长期、有针对性地输送治疗剂。

更新日期：2024-08-07

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