Small RNAs base pair with and regulate mRNA translation and stability. For both bacterial small regulatory RNAs and eukaryotic microRNAs, association with partner proteins is critical for the stability and function of the regulatory RNAs. We review the mechanisms for degradation of these RNAs: displacement of the regulatory RNA from its protein partner (in bacteria) or destruction of the protein and its associated microRNAs (in eukaryotes). These mechanisms can allow specific destruction of a regulatory RNA via pairing with a decay trigger RNA or function as global off switches by disrupting the stability or function of the protein partner.

中文翻译：

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上升必然下降：调节 RNA 的开关


小 RNA 碱基配对并调节 mRNA 翻译和稳定性。对于细菌小调节 RNA 和真核 microRNA 来说，与伴侣蛋白的结合对于调节 RNA 的稳定性和功能至关重要。我们回顾了这些 RNA 降解的机制：调节性 RNA 从其蛋白质伴侣（在细菌中）中置换出来，或破坏蛋白质及其相关的 microRNA（在真核生物中）。这些机制可以通过与衰变触发 RNA 配对来特异性破坏调节 RNA，或者通过破坏蛋白质伴侣的稳定性或功能来充当全局开关。