Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals, including dogs and cats. Obesity occurs with multiple comorbidities, such as diabetes, hypertension, heart disease and osteoarthritis in dogs and cats. A direct link between lipid metabolism dysregulation and obesity-associated diseases has been implicated. However, the understanding of such pathophysiology in companion animals is limited. This review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity, emphasizing the involvement of the gut microbiota. Furthermore, we also discuss the management of obesity, including approaches like nutritional interventions, thus providing novel insights into obesity prevention and treatment for canines and felines.

中文翻译：

---

深入了解肠道微生物群与脂质代谢在犬科动物和猫科动物肥胖管理中的相互作用


肥胖是一种普遍存在的慢性疾病，对人类和我们的伴侣动物（包括狗和猫）产生重大负面影响。肥胖会伴随多种合并症，例如狗和猫的糖尿病、高血压、心脏病和骨关节炎。脂质代谢失调与肥胖相关疾病之间存在直接联系。然而，对伴侣动物的这种病理生理学的理解是有限的。本综述旨在探讨脂质代谢在与肥胖相关的各种代谢紊乱中的作用，强调肠道微生物群的参与。此外，我们还讨论了肥胖的管理，包括营养干预等方法，从而为犬科动物和猫科动物的肥胖预防和治疗提供了新的见解。