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Integrated Sensing Platform Validated for the Efficient and On-Site Screening of Amine-Containing Illicit Drugs
ACS Sensors ( IF 8.2 ) Pub Date : 2024-08-08 , DOI: 10.1021/acssensors.4c00787 Jiashuang Yao 1 , Chun Yang 2 , Ruijuan Wen 1 , Taihong Liu 1 , Liping Ding 1 , Zhen Yao 2 , Yu Fang 1
ACS Sensors ( IF 8.2 ) Pub Date : 2024-08-08 , DOI: 10.1021/acssensors.4c00787 Jiashuang Yao 1 , Chun Yang 2 , Ruijuan Wen 1 , Taihong Liu 1 , Liping Ding 1 , Zhen Yao 2 , Yu Fang 1
Affiliation
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Efficient and reliable technologies for the on-site detection of illicit drugs are important in drug-facilitated crime investigations. However, the development of such technologies is challenging. Based on the synthetic optimization, introducing a boron ester functional group to the two furanic indicators endows the stimulus-responsive properties synergistically. The ring-opening reaction of the indicators in the presence of amine-containing illicit drugs generated well-known donor–acceptor Stenhouse adducts, accompanied by strong color changes. A small-size and lightweight laminated sensor was integrated based on the outstanding ratiometric variations of the two active furanic indicators. A prototype platform was fabricated equipped with a circuit control, a mini pump, and a signal processing system. A user-friendly detection and efficient screening of amine-containing illicit drugs, including phenethylamines, amphetamines, cathinones, and tryptamines in the liquid states were conducted. The ratiometric response of the sensor was linear in the concentration range of 2.1–10.6 μg·mL–1 for methamphetamine·HCl and methcathinone ·HCl. The detection limits for the two illicit drugs at the sublevel (ng·mL–1) were found to be 8.4 and 9.0 ng·mL–1, respectively. Double-blind field tests and different illicit drugs were evaluated with good screening capability. Successful trials showed the potential applications of the developed prototype platform for efficient and on-site analytical determination.
中文翻译：
经验证可有效现场筛查含胺非法药物的集成传感平台
高效、可靠的非法药物现场检测技术对于毒品犯罪调查非常重要。然而，此类技术的开发具有挑战性。在合成优化的基础上，在两种呋喃指示剂中引入硼酯官能团，协同赋予了刺激响应特性。在含胺非法药物存在下，指示剂的开环反应产生了众所周知的供体-受体斯滕豪斯加合物，并伴有强烈的颜色变化。基于两种活性呋喃指示剂的出色比率变化，集成了小尺寸、轻重量的层压传感器。原型平台配备了电路控制、微型泵和信号处理系统。对液态苯乙胺、安非他明、卡西酮和色胺等含胺非法药物进行了用户友好的检测和有效筛查。对于甲基苯丙胺·HCl 和甲卡西酮·HCl，传感器的比率响应在2.1–10.6 μg·mL –1浓度范围内呈线性。两种违禁药物亚水平（ng·mL –1 ）的检出限分别为8.4和9.0 ng·mL –1 。双盲现场试验和不同违禁药物的评价具有良好的筛查能力。成功的试验表明了所开发的原型平台在高效现场分析测定方面的潜在应用。
更新日期：2024-08-08
中文翻译：
经验证可有效现场筛查含胺非法药物的集成传感平台
高效、可靠的非法药物现场检测技术对于毒品犯罪调查非常重要。然而，此类技术的开发具有挑战性。在合成优化的基础上，在两种呋喃指示剂中引入硼酯官能团，协同赋予了刺激响应特性。在含胺非法药物存在下，指示剂的开环反应产生了众所周知的供体-受体斯滕豪斯加合物，并伴有强烈的颜色变化。基于两种活性呋喃指示剂的出色比率变化，集成了小尺寸、轻重量的层压传感器。原型平台配备了电路控制、微型泵和信号处理系统。对液态苯乙胺、安非他明、卡西酮和色胺等含胺非法药物进行了用户友好的检测和有效筛查。对于甲基苯丙胺·HCl 和甲卡西酮·HCl，传感器的比率响应在2.1–10.6 μg·mL –1浓度范围内呈线性。两种违禁药物亚水平（ng·mL –1 ）的检出限分别为8.4和9.0 ng·mL –1 。双盲现场试验和不同违禁药物的评价具有良好的筛查能力。成功的试验表明了所开发的原型平台在高效现场分析测定方面的潜在应用。
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