Epithelial–Mesenchymal Transition Related Score Functions as a Predictive Tool for Immunotherapy and Candidate Drugs in Glioma,Journal of Chemical Information and Modeling

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Epithelial–Mesenchymal Transition Related Score Functions as a Predictive Tool for Immunotherapy and Candidate Drugs in Glioma
Journal of Chemical Information and Modeling ( IF 5.6 ) Pub Date : 2024-08-08 , DOI: 10.1021/acs.jcim.4c00620
Xiaojun Fu _{1,

2} , Changyuan Ren _{1,

3} , Kaining Dai _{1,

2} , Ming Ren ₁ , Changxiang Yan ₁

Affiliation

Gliomas are aggressive CNS tumors where the epithelial–mesenchymal transition (EMT) is crucial for prognosis. We developed an EMT-based score predicting overall survival (OS) and conducted pathway analyses, revealing functions such as cell proliferation and immune response in glioma progression. The EMT score, correlated with immune functions and cell infiltration, shows potential as an immune response indicator. We identified two promising compounds, BIX02189 and QL-XI-92, as potential glioma treatments based on candidate gene analysis.

中文翻译：

上皮-间质转化相关评分功能作为神经胶质瘤免疫治疗和候选药物的预测工具

胶质瘤是一种侵袭性中枢神经系统肿瘤，其中上皮间质转化（EMT）对于预后至关重要。我们开发了基于 EMT 的评分来预测总生存期 (OS)，并进行了通路分析，揭示了神经胶质瘤进展中的细胞增殖和免疫反应等功能。 EMT 评分与免疫功能和细胞浸润相关，显示出作为免疫反应指标的潜力。我们根据候选基因分析确定了两种有前景的化合物 BIX02189 和 QL-XI-92 作为潜在的神经胶质瘤治疗方法。

更新日期：2024-08-08

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