Chemical Antiquity in Metabolism,Accounts of Chemical Research

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Chemical Antiquity in Metabolism
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2024-07-31 , DOI: 10.1021/acs.accounts.4c00226
Natalia Mrnjavac ₁ , Loraine Schwander ₁ , Max Brabender ₁ , William F Martin ₁

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Life is an exergonic chemical reaction. The same was true when the very first cells emerged at life’s origin. In order to live, all cells need a source of carbon, energy, and electrons to drive their overall reaction network (metabolism). In most cells, these are separate pathways. There is only one biochemical pathway that serves all three needs simultaneously: the acetyl-CoA pathway of CO₂ fixation. In the acetyl-CoA pathway, electrons from H₂ reduce CO₂ to pyruvate for carbon supply, while methane or acetate synthesis are coupled to energy conservation as ATP. This simplicity and thermodynamic favorability prompted Georg Fuchs and Erhard Stupperich to propose in 1985 that the acetyl-CoA pathway might mark the origin of metabolism, at the same time that Steve Ragsdale and Harland Wood were uncovering catalytic roles for Fe, Co, and Ni in the enzymes of the pathway. Subsequent work has provided strong support for those proposals.

中文翻译：

新陈代谢中的化学古物

生命是一种放能的化学反应。当生命起源时第一个细胞出现时也是如此。为了生存，所有细胞都需要碳源、能量和电子来驱动其整体反应网络（新陈代谢）。在大多数细胞中，这些是单独的途径。只有一种生化途径可以同时满足所有三种需求：CO ₂固定的乙酰辅酶A途径。在乙酰辅酶A途径中，来自H ₂的电子将CO ₂还原为丙酮酸以提供碳，而甲烷或乙酸盐的合成则与能量守恒耦合为ATP。这种简单性和热力学优势促使 Georg Fuchs 和 Erhard Stupperich 在 1985 年提出，乙酰辅酶 A 途径可能标志着新陈代谢的起源，同时 Steve Ragsdale 和 Harland Wood 发现了 Fe、Co 和 Ni 在代谢过程中的催化作用。该途径的酶。随后的工作为这些建议提供了强有力的支持。

更新日期：2024-07-31

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