Disulfide-stabilized trimeric hemagglutinin ectodomains provide enhanced heterologous influenza protection,Emerging Microbes & Infections

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Disulfide-stabilized trimeric hemagglutinin ectodomains provide enhanced heterologous influenza protection
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2024-08-18 , DOI: 10.1080/22221751.2024.2389095
De-Jian Liu ₁ , Xiu-Qin Zhong ₁ , Yan-Xia Ru ₂ , Shi-Long Zhao ₁ , Cui-Cui Liu ₁ , Yi-Bo Tang ₁ , Xuan Wu ₁ , Yi-Shuai Zhang ₃ , Hui-Hui Zhang ₃ , Jia-Yue She ₁ , Mu-Yang Wan ₁ , Yao-Wang Li ₂ , He-Ping Zheng ₃ , Lei Deng _{1,

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Affiliation

Influenza virus infection poses a continual menace to public health. Here, we developed soluble trimeric HA ectodomain vaccines by establishing interprotomer disulfide bonds in the stem region, whi...

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