Heterologous mRNA/MVA delivering trimeric-RBD as effective vaccination regimen against SARS-CoV-2: COVARNA Consortium,Emerging Microbes & Infections

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Heterologous mRNA/MVA delivering trimeric-RBD as effective vaccination regimen against SARS-CoV-2: COVARNA Consortium
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2024-08-08 , DOI: 10.1080/22221751.2024.2387906
Laura Marcos-Villar _{1,

2} , Beatriz Perdiguero _{1,

2} , María López-Bravo ₃ , Carmen Zamora ₁ , Laura Sin _{1,

2} , Enrique Álvarez ₁ , Carlos Óscar S Sorzano ₄ , Pedro J Sánchez-Cordón ₅ , José M Casasnovas ₆ , David Astorgano ₁ , Juan García-Arriaza _{1,

2} , Shubaash Anthiya ₇ , Mireya L Borrajo ₇ , Gustavo Lou ₇ , Belén Cuesta ₇ , Lorenzo Franceschini ₈ , Josep L Gelpí _{9,

10} , Kris Thielemans ₈ , Marta Sisteré-Oró ₁₁ , Andreas Meyerhans _{11,

12} , Felipe García _{13,

14} , Ignasi Esteban ₁₄ , Núria López-Bigas _{12,

15,

16} , Montserrat Plana _{2,

14} , María J Alonso _{7,

17} , Mariano Esteban ₁ , Carmen Elena Gómez _{1,

2}

Affiliation

Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Department of Microbial Biotechnology, CNB, CSIC, Madrid, Spain.
Biocomputing Unit and Computational Genomics, CNB, CSIC, Madrid, Spain.
Veterinary Pathology Department, Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), CSIC, Madrid, Spain.
Department of Macromolecular Structures, CNB, CSIC, Madrid, Spain.
Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Laboratory for Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Barcelona Supercomputing Center (BSC), Barcelona, Spain.
Department of Biochemistry and Molecular Biomedicine, University of Barcelona (UB), Barcelona, Spain.
Infection Biology Laboratory, Department of Medicine and Life Sciences, University Pompeu Fabra, Barcelona, Spain.
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Infectious Diseases Department, Hospital Clínic, UB, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, UB, Barcelona, Spain.
Institute for Research in Biomedicine (IRB), Barcelona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain.

Despite the high efficiency of current SARS-CoV-2 mRNA vaccines in reducing COVID-19 morbidity and mortality, waning immunity and the emergence of resistant variants underscore the need for novel v...

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