A new study suggests that glial cells in both Huntington disease (HD) and schizophrenia share abnormal gene transcription patterns. RNA sequencing of glial progenitor cells derived from human pluripotent stem cells revealed preserved gene sets between the diseases that were distinct from healthy control donors. A large proportion of genes that were supressed in both diseases are involved in synaptic signalling, including OLIG2, TCF7L2 and ADGRL3, which regulate glutamate signalling. The results indicate that supressed glial receptivity to glutamate could contribute to pathology in both HD and schizophrenia.

中文翻译：

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HD 和精神分裂症的共同神经胶质病理学

一项新的研究表明，亨廷顿病（HD）和精神分裂症中的神经胶质细胞具有异常的基因转录模式。对源自人类多能干细胞的神经胶质祖细胞进行的 RNA 测序揭示了与健康对照供体不同的疾病之间保留的基因组。在这两种疾病中被抑制的大部分基因都与突触信号传导有关，包括调节谷氨酸信号传导的OLIG2 、 TCF7L2和ADGRL3 。结果表明，神经胶质细胞对谷氨酸的接受性受到抑制可能会导致亨廷顿舞蹈症和精神分裂症的病理。