Biomedical SERS – the current state and future trends,Chemical Society Reviews

当前位置： X-MOL 学术 › Chem. Soc. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Biomedical SERS – the current state and future trends
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-08-07 , DOI: 10.1039/d4cs00090k
Dana Cialla-May _{1,

2} , Alois Bonifacio ₃ , Thomas Bocklitz _{1,

2,

4} , Alexey Markin ₅ , Natalia Markina ₅ , Stefano Fornasaro ₆ , Aradhana Dwivedi _{1,

2} , Tony Dib _{1,

2} , Edoardo Farnesi ₂ , Chen Liu _{1,

2} , Arna Ghosh _{1,

2} , Juergen Popp _{1,

2}

Affiliation

Surface enhanced Raman spectroscopy (SERS) is meeting the requirements in biomedical science being a highly sensitive and specific analytical tool. By employing portable Raman systems in combination with customized sample pre-treatment, point-of-care-testing (POCT) becomes feasible. Powerful SERS-active sensing surfaces with high stability and modification layers if required are available for testing and application in complex biological matrices such as body fluids, cells or tissues. This review summarizes the current state in sample collection and pretreatment in SERS detection protocols, SERS detection schemes, i.e. direct and indirect SERS as well as targeted and non-targeted SERS, and SERS-active sensing surfaces. Moreover, the recent developments and advances of SERS in biomedical application scenarios, such as infectious diseases, cancer diagnostics and therapeutic drug monitoring is given, which enables the readers to identify the sample collection and preparation protocols, SERS substrates and detection strategies that are best-suited for their specific applications in biomedicine.

中文翻译：

生物医学SERS——现状和未来趋势

表面增强拉曼光谱（SERS）作为一种高度灵敏和特异性的分析工具，满足生物医学的要求。通过采用便携式拉曼系统与定制样品预处理相结合，即时检测 (POCT) 变得可行。强大的 SERS 活性传感表面具有高稳定性和修饰层（如果需要）可用于复杂生物基质（如体液、细胞或组织）的测试和应用。本综述总结了 SERS 检测方案、SERS 检测方案（即直接和间接 SERS、靶向和非靶向 SERS 以及 SERS 活性传感表面）中样品采集和预处理的现状。此外，还给出了SERS在传染病、癌症诊断和治疗药物监测等生物医学应用场景中的最新发展和进展，使读者能够确定最佳的样品采集和制备方案、SERS底物和检测策略。适合其在生物医学中的特定应用。

更新日期：2024-08-07

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南