Plasma-treated gold microelectrodes for subsecond detection of Zn(II) with fast-scan cyclic voltammetry,Analyst

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Plasma-treated gold microelectrodes for subsecond detection of Zn(II) with fast-scan cyclic voltammetry
Analyst ( IF 3.6 ) Pub Date : 2024-08-07 , DOI: 10.1039/d4an00307a
Anntonette N Perry ₁ , Romana Jarosova ₁ , Colby E Witt ₁ , Moriah E Weese-Myers ₁ , Vivek Subedi ₁ , Ashley E Ross ₁

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The sensitivity of zinc (Zn(II)) detection using fast-scan cyclic voltammetry (FSCV) with carbon fiber microelectrodes (CFMEs) is low compared to other neurochemicals. We have shown previously that Zn(II) plates to the surface of CFME's and we speculate that it is because of the abundance of oxide functionality on the surface. Plating reduces sensitivity over time and causes significant disruption to detection stability. This limited sensitivity and stability hinders Zn(II) detection, especially in complex matrices like the brain. To address this, we developed plasma-treated gold fiber microelectrodes (AuMEs) which enable sensitive and stable Zn(II) detection with FSCV. Typically, gold fibers are treated using corrosive acids to clean the surface and this step is important for preparing the surface for electrochemistry. Likewise, because FSCV is an adsorption-based technique, it is also important for Zn(II) to adsorb and desorb to prevent irreversible plating. Because of these requirements, careful optimization of the electrode surface was necessary to render the surface for Zn(II) adsorption yet strike a balance between attraction to the surface vs. irreversible interactions. In this study, we employed oxygen plasma treatment to activate the gold fiber surface without inducing significant morphological changes. This treatment effectively removes the organic layer while functionalizing the surface with oxygen, enabling Zn(II) detection that is not possible on untreated gold surfaces. Our results demonstrate significantly improved Zn(II) detection sensitivity and stability on AuME compared to CFME's. Overall, this work provides an advance in our understanding of Zn(II) electrochemistry and a new tool for improved metallotransmitter detection in the brain.

中文翻译：

经等离子体处理的金微电极，用于通过快速扫描循环伏安法亚秒级检测 Zn(II)

与其他神经化学物质相比，使用快速扫描循环伏安法 (FSCV) 和碳纤维微电极 (CFME) 检测锌 (Zn( II )) 的灵敏度较低。我们之前已经表明，Zn( II ) 镀在 CFME 的表面，我们推测这是因为表面上存在丰富的氧化物官能团。随着时间的推移，电镀会降低灵敏度，并对检测稳定性造成严重破坏。这种有限的灵敏度和稳定性阻碍了 Zn( II ) 的检测，尤其是在大脑等复杂基质中。为了解决这个问题，我们开发了经过等离子体处理的金纤维微电极 (AuME)，它能够通过 FSCV 进行灵敏且稳定的 Zn( II ) 检测。通常，金纤维使用腐蚀性酸进行处理以清洁表面，此步骤对于准备电化学表面非常重要。同样，由于 FSCV 是一种基于吸附的技术，因此 Zn( II ) 的吸附和解吸对于防止不可逆电镀也很重要。由于这些要求，必须仔细优化电极表面，以使表面能够吸附 Zn( II )，同时在表面吸引力与不可逆相互作用之间取得平衡。在这项研究中，我们采用氧等离子体处理来激活金纤维表面，而不引起显着的形态变化。这种处理有效地去除了有机层，同时用氧对表面进行功能化，从而实现了 Zn( II ) 检测，而这在未经处理的金表面上是不可能的。我们的结果表明，与 CFME 相比，AuME 的 Zn( II ) 检测灵敏度和稳定性显着提高。总体而言，这项工作加深了我们对 Zn( II ) 电化学的理解，并为改进大脑中的金属递质检测提供了新工具。

更新日期：2024-08-07

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