Aluminum oxide nanoparticles (Al2O3 NPs) are among the most extensively utilized nanoparticles in nanotechnology and that have negative impacts on the environment. Therefore, the intention of this work is to investigate the protective and therapeutic effects of curcumin in nanoform (Cur NPs) against Al2O3 NPs induced kidney toxicity, oxidative stress, DNA damage, and changes in necrosis factor alpha (TNFα) and proliferating cell nuclear antigen (PCNA) expressions in male rats. Fifty healthy adult male were divided into five groups [G1, control; G2, received 50 mg/kg/day for 4 weeks of Cur NPs orally; G3, received 6 mg/kg BW orally for 4 weeks of Al2O3 NPs; G4, (Cur NPs + Al2O3 NPs) received Cur NPs and Al2O3 NPs at a dose similar to G2 and G3, respectively for 4 weeks; G5, (Al2O3 NPs + Cur NPs) received Al2O3 NPs at a dose similar to G3 for 4 weeks then received Cur NPs at a dose similar to G2 for another 4 weeks]. Current results revealed that Al2O3 NPs induced a significant elevation in serum urea, creatinine, chloride, calcium, kidney malondialdehyde (MDA), DNA damage, injury, TNFα and PCNA expressions and a significant depletion in serum potassium, kidney superoxide dismutase (SOD), glutathione (GSH) as compared to control. On the other hand, treatments of Al2O3 NPs with Cur NPs induced modulation in all altered parameters and improved kidney functions and structure, with best results for the Al2O3 NPs + Cur NPs than Cur NPs + Al2O3 NPs. In conclusion, Cur NPs has the capacity to mitigate the renal toxicity induced by Al2O3 NPs in male albino rats.

中文翻译：

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姜黄素纳米颗粒对氧化铝纳米颗粒的改善和治疗作用诱导雄性大鼠肾毒性、DNA 损伤、氧化应激、PCNA 和 TNFα 改变


氧化铝纳米颗粒 （Al2O3 NPs） 是纳米技术中使用最广泛的纳米颗粒之一，对环境有负面影响。因此，这项工作的目的是研究纳米型姜黄素 （Cur NPs） 对 Al2O3 NPs 诱导的肾毒性、氧化应激、DNA 损伤以及坏死因子 α （TNFα） 和增殖细胞核抗原 （PCNA） 表达的变化的保护和治疗作用雄性大鼠。将 50 名健康成年男性分为 5 组 [G1，对照;G2，口服 50 mg/kg/天，持续 4 周;G3，口服 6 mg/kg BW 4 周的 Al2O3 NPs;G4 （Cur NPs + Al2O3 NPs） 分别以与 G2 和 G3 相似的剂量接受 Cur NPs 和 Al2O3 NPs，持续 4 周;G5，（Al2O3 NPs + Cur NPs）接受剂量与 G3 相似的 Al2O3 NPs 4 周，然后接受剂量与 G2 相似的 Cur NPs 再治疗 4 周]。目前的结果表明，与对照组相比，Al2O3 NPs 诱导血清尿素、肌酐、氯化物、钙、肾丙二醛 （MDA）、DNA 损伤、损伤、TNFα 和 PCNA 表达显著升高，血清钾、肾超氧化物歧化酶 （SOD）、谷胱甘肽 （GSH） 显著耗竭。另一方面，用 Cur NPs 处理 Al2O3 NPs 诱导了所有改变参数的调节，并改善了肾功能和结构，Al2O3 NPs + Cur NPs 的结果优于 Cur NPs + Al2O3 NPs。总之，Cur NPs 具有减轻 Al2O3 NPs 诱导的雄性白化大鼠肾毒性的能力。