ObjectivesTo date, no studies have exploited micro‐CT in humans to evaluate bone morphology and structure after bone augmentation with CAD/CAM‐customized titanium mesh, in mandible and maxilla. The aim of this study was to assess the composition and microstructure of bone biopsy through micro‐CT analysis.Materials and MethodsBone augmentation at both maxillary and mandible sites was performed on 30 patients randomly treated with customized mesh, either alone (M−) or covered with resorbable membrane (M+), in both cases filled 50:50 with autogenous bone and xenograft. After 6 months, biopsies were taken and micro‐CT was performed on consecutive 1‐mm‐thick VOIs from coronal to apical side, measuring tissue volumes, trabecular thickness, spacing, and number.ResultsIn both groups, irrespective of membrane use, bone tissue (M−: 29.76% vs. M+: 30.84%) and residual graft material (M−: 14.87% vs. M+: 13.11%) values were similar. Differences were site‐related (maxillary vs. mandibular) with higher percentage of bone tissue and trabecular density of low‐mineralized bone and overall bone in the mandible.ConclusionsThe composition and structure of bone tissue, as assessed by micro‐CT after alveolar ridge augmentation using CAD/CAM‐customized titanium meshes, showed similar features regardless of whether a collagen membrane was applied.

中文翻译：

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使用 CAD/CAM 定制的钛网对垂直和水平牙槽嵴增强术后骨组织的组成和结构进行 3D 显微 CT 评估


目的迄今为止，还没有研究利用人体显微 CT 来评估使用 CAD/CAM 定制的钛网进行下颌骨和上颌骨骨增强后的骨骼形态和结构。本研究的目的是通过显微 CT 分析评估骨活检的成分和微观结构。材料和方法对 30 例随机接受定制网片治疗的患者进行上颌骨和下颌骨部位的骨增强，单独 （M−） 或覆盖可吸收膜 （M+），在两种情况下都以 50：50 的比例填充自体骨和异种移植物。6 个月后，进行活检，对从冠状面到根尖侧的连续 1 mm 厚的 VOI 进行显微 CT，测量组织体积、小梁厚度、间距和数量。结果在两组中，无论膜的使用如何，骨组织 （M−： 29.76% vs. M+： 30.84%） 和残留移植物材料 （M−： 14.87% vs. M+： 13.11%） 值相似。差异是与部位相关的 （上颌骨与下颌骨），下颌骨中低矿化骨和整体骨的骨组织和小梁密度百分比更高。结论使用 CAD/CAM 定制的钛网进行牙槽嵴增强后通过显微 CT 评估的骨组织的组成和结构，无论是否应用胶原膜，都显示出相似的特征。