Cancer vaccines are an approach to elicit amplified antigen-specific immune responses. Induced pluripotent stem cells (iPSCs) have potential utility for the development of universal vaccines due to their intrinsic antigenic epitopes. Concurrently, iPSCs can undergo pluripotent differentiation and are thus a stable source of both antigen-presenting cells for producing immune cell-based vaccines and tumor organoids for facilitating the exploration and adaptive assessment of tumor vaccines. This review describes the specific contributions of iPSCs to vaccine development, summarizes their diverse developmental trajectories, and discusses the obstacles to their application along with potential solutions.

中文翻译：

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诱导多能干细胞促进癌症疫苗的开发和评估


癌症疫苗是一种引发扩增抗原特异性免疫反应的方法。诱导多能干细胞 （iPSC） 由于其内在抗原表位而具有开发通用疫苗的潜在用途。同时，iPSC 可以进行多能分化，因此是抗原呈递细胞的稳定来源，用于生产基于免疫细胞的疫苗和肿瘤类器官，用于促进肿瘤疫苗的探索和适应性评估。本文介绍了 iPSCs 对疫苗开发的具体贡献，总结了它们不同的开发轨迹，并讨论了其应用的障碍以及可能的解决方案。