Engineering Cells for Cancer Therapy,Accounts of Chemical Research

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Engineering Cells for Cancer Therapy
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2024-08-02 , DOI: 10.1021/acs.accounts.4c00293
Peixin Liu _{1,

2,

3} , Quanyin Hu _{1,

2,

3}

Affiliation

Cells, particularly living cells, serve as natural carriers of bioactive substances. Their inherent low immunogenicity and multifunctionality have garnered significant attention in the realm of disease treatment applications, specifically within the domains of cancer immunotherapy and regenerative tissue repair. Nevertheless, several prominent challenges impede their swift translation into clinical applications, including obstacles related to large-scale production feasibility and high utilization costs. To address these issues comprehensively, researchers have proposed the notion of bionic cells that are synthetically generated through chemical or biosynthetic means to emulate cellular functions and behaviors. However, artificial cell strategies encounter difficulties in fully replicating the intricate functionalities exhibited by living cells while also grappling with the complexities associated with design implementation for clinical translation purposes. The convergence of disciplines has facilitated the reform of living cells through a range of approaches, including chemical-, biological-, genetic-, and materials-based methods. These techniques can be employed to impart specific functions to cells or enhance the efficacy of therapy. For example, cells are engineered through gene transduction, surface modifications, endocytosis of drugs as delivery systems, and membrane fusion. The concept of engineered cells presents a promising avenue for enhancing control over living cells, thereby enhancing therapeutic efficacy while concurrently mitigating toxic side effects and ultimately facilitating the realization of precision medicine.

中文翻译：

用于癌症治疗的工程细胞

细胞，尤其是活细胞，是生物活性物质的天然载体。它们固有的低免疫原性和多功能性在疾病治疗应用领域引起了广泛关注，特别是在癌症免疫治疗和再生组织修复领域。然而，一些突出的挑战阻碍了它们迅速转化为临床应用，包括与大规模生产可行性和高利用成本相关的障碍。为了全面解决这些问题，研究人员提出了通过化学或生物合成方式合成产生的仿生细胞的概念，以模拟细胞的功能和行为。然而，人工细胞策略在完全复制活细胞所表现出的复杂功能方面遇到了困难，同时还要努力解决与临床转化目的的设计实施相关的复杂性。学科的融合通过一系列方法促进了活细胞的改革，包括基于化学、生物、遗传和材料的方法。这些技术可用于赋予细胞特定功能或增强治疗效果。例如，细胞是通过基因转导、表面修饰、药物作为递送系统的内吞作用和膜融合进行工程改造的。工程细胞的概念为加强对活细胞的控制提供了一条有前途的途径，从而提高治疗效果，同时减轻毒副作用，并最终促进精准医疗的实现。

更新日期：2024-08-02

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