The Ruminant Telomere-to-Telomere (RT2T) Consortium,Nature Genetics

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The Ruminant Telomere-to-Telomere (RT2T) Consortium
Nature Genetics ( IF 31.7 ) Pub Date : 2024-08-05 , DOI: 10.1038/s41588-024-01835-2
Theodore S Kalbfleisch ₁ , Stephanie D McKay ₂ , Brenda M Murdoch ₃ , David L Adelson ₄ , Diego Almansa-Villa ₅ , Gabrielle Becker ₃ , Linda M Beckett ₆ , María José Benítez-Galeano ₅ , Fernando Biase ₇ , Theresa Casey ₆ , Edward Chuong ₈ , Emily Clark ₉ , Shannon Clarke ₁₀ , Noelle Cockett ₁₁ , Christine Couldrey ₁₂ , Brian W Davis ₁₃ , Christine G Elsik ₂ , Thomas Faraut ₁₄ , Yahui Gao ₁₅ , Carine Genet ₁₄ , Patrick Grady ₁₆ , Jonathan Green ₂ , Richard Green ₁₆ , Dailu Guan ₁₇ , Darren Hagen ₁₈ , Gabrielle A Hartley ₁₆ , Mike Heaton ₁₉ , Savannah J Hoyt ₁₆ , Wen Huang ₂₀ , Erich Jarvis _{21,

22} , Jenna Kalleberg ₂ , Hasan Khatib ₂₃ , Klaus-Peter Koepfi _{24,

25} , James Koltes ₂₆ , Sergey Koren ₂₇ , Christa Kuehn ₂₈ , Tosso Leeb ₂₉ , Alexander Leonard ₃₀ , George E Liu ₁₅ , Wai Yee Low ₃₁ , Hunter McConnell ₂ , Kathryn McRae ₁₀ , Karen Miga _{32,

33} , Michelle Mousel _{34,

35} , Holly Neibergs ₃₆ , Temitayo Olagunju ₃ , Matt Pennell ₃₇ , Bruna Petry ₂₆ , Mirjam Pewsner ₃₈ , Adam M Phillippy ₂₇ , Brandon D Pickett ₂₇ , Paulene Pineda ₃₁ , Tamara Potapova ₃₉ , Satyanarayana Rachagani ₄₀ , Arang Rhie ₂₇ , Monique Rijnkels ₄₁ , Annie Robic ₁₄ , Nelida Rodriguez Osorio ₅ , Yana Safonova ₄₂ , Gustavo Schettini ₇ , Robert D Schnabel ₂ , Nagabhishek Sirpu Natesh ₄₃ , Morgan Stegemiller ₃ , Jessica Storer ₄₄ , Paul Stothard ₄₅ , Caleb Stull ₂ , Gwenola Tosser-Klopp ₁₄ , Germán M Traglia ₅ , Christopher K Tuggle ₂₆ , Curtis P Van Tassell ₁₅ , Corey Watson ₄₆ , Rosemarie Weikard ₄₇ , Klaus Wimmers ₄₇ , Shangqian Xie ₃ , Liu Yang ₁₅ , Timothy P L Smith ₁₉ , Rachel J O'Neill _{16,

44} , Benjamin D Rosen ₁₅

Affiliation

Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
Division of Animal Sciences, University of Missouri, Columbia, MO, USA.
Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID, USA.
School of Biological Sciences, the University of Adelaide, North Terrace, Adelaide, South Australia, Australia.
Genomics and Bioinformatics Unit, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.
School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
BioFrontiers Institute, Department of Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
The Roslin Institute, University of Edinburgh, Edinburgh, UK.
Invermay Agricultural Centre, AgResearch Ltd, Mosgiel, New Zealand.
Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Livestock Improvement Corporation, Hamilton, New Zealand.
Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
GenPhySE, Université de Toulouse, INRAE, ENVT, Castanet Tolosan, France.
Animal Genomics and Improvement Laboratory, USDA ARS, Beltsville, MD, USA.
Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Department of Animal Science, University of California, Davis, Davis, CA, USA.
Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, USA.
U.S. Meat Animal Research Center, USDA ARS, Clay Center, NE, USA.
Department of Animal Science, Michigan State University, East Lansing, MI, USA.
Vertebrate Genome Laboratory, the Rockefeller University, New York, NY, USA.
Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Department of Animal and Dairy Sciences, the University of Wisconsin-Madison, Madison, WI, USA.
Smithsonian-Mason School of Conservation, George Mason University, Front Royal, VA, USA.
Center for Species Survival, Smithsonian's National Zoo and Conservation Biology Institute, Front Royal, VA, USA.
Department of Animal Science, Iowa State University, Ames, IA, USA.
Genome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Friedrich-Loeffler-Institute (German Federal Research Institute for Animal Health), Greifswald-Insel Riems, Germany.
Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Animal Genomics, ETH Zürich, Zurich, Switzerland.
The Davies Research Centre, School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, South Australia, Australia.
UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
Biomolecular Engineering Department, University of California, Santa Cruz, Santa Cruz, CA, USA.
Animal Disease Research Unit, USDA ARS, Pullman, WA, USA.
School for Global Animal Health, Washington State University, Pullman, WA, USA.
Department of Animal Science, Washington State University, Pullman, WA, USA.
Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.
Institute of Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Stowers Institute for Medical Research, Kansas City, MO, USA.
Veterinary Medicine and Surgery, NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA.
Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Computer Science and Engineering Department, Huck Institutes of the Life Sciences, Pennsylvania State University, State College, PA, USA.
Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, USA.
Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.
Institute of Genome Biology, Research Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.

Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously ‘invisible’ parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the ‘Ruminant T2T Consortium’ (RT2T), that aims to generate complete diploid assemblies for numerous species of the Artiodactyla suborder Ruminantia to examine chromosomal evolution in the context of natural selection and domestication of species used as livestock.

中文翻译：

反刍动物端粒到端粒 (RT2T) 联盟

端粒到端粒（T2T）组装揭示了对基因组先前“不可见”部分的结构和功能的新见解，并允许对整个进化枝的完整基因组进行比较分析。我们在此提出一项名为“反刍动物 T2T 联盟”(RT2T) 的开放式合作项目，旨在为偶蹄目反刍亚目的众多物种生成完整的二倍体组装体，以在自然选择和驯化物种的背景下检查染色体进化。家畜。

更新日期：2024-08-05

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