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Interplay of Food-Derived Bioactive Peptides with Gut Microbiota: Implications for Health and Disease Management
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-04 , DOI: 10.1002/mnfr.202400251 Mingyang Hu 1 , Yufeng Du 1 , Wenyue Li 1 , Xiaomei Zong 1 , Wenjuan Du 1 , Huizeng Sun 2 , Hongyun Liu 2 , Ke Zhao 3 , Jianxiong Li 4 , Muhammad Zahid Farooq 5 , Jianping Wu 6 , Qingbiao Xu 1
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-04 , DOI: 10.1002/mnfr.202400251 Mingyang Hu 1 , Yufeng Du 1 , Wenyue Li 1 , Xiaomei Zong 1 , Wenjuan Du 1 , Huizeng Sun 2 , Hongyun Liu 2 , Ke Zhao 3 , Jianxiong Li 4 , Muhammad Zahid Farooq 5 , Jianping Wu 6 , Qingbiao Xu 1
Affiliation
Bioactive peptides (BPs) are protein fragments with beneficial effects on metabolism, physiology, and diseases. This review focuses on proteolytic BPs, which are produced by the action of gut microbiota on proteins in food and have demonstrated to influence the composition of gut microbes. And gut microbiota are candidate targets of BPs to alleviate oxidative stress, enhance immunity, and control diseases, including diabetes, hypertension, obesity, cancer, and immune and neurodegenerative diseases. Despite promising results, further research is needed to understand the mechanisms underlying the interactions between BPs and gut microbes, and to identify and screen more BPs for industrial applications. Overall, BPs offer potential as therapeutic agents for various diseases through their interactions with gut microbes, highlighting the importance of continued research in this area.
中文翻译:
食物来源的生物活性肽与肠道微生物群的相互作用:对健康和疾病管理的影响
生物活性肽 (BPs) 是对新陈代谢、生理和疾病有有益影响的蛋白质片段。本综述重点介绍蛋白水解 BPs,它是由肠道微生物群对食物中蛋白质的作用产生的,并已被证明会影响肠道微生物的组成。肠道菌群是 BP 的候选靶点,可缓解氧化应激、增强免疫力和控制疾病,包括糖尿病、高血压、肥胖、癌症以及免疫和神经退行性疾病。尽管取得了有希望的结果,但仍需要进一步的研究来了解 BPs 与肠道微生物之间相互作用的潜在机制,并识别和筛选更多用于工业应用的 BPs。总体而言,BP 通过与肠道微生物的相互作用提供了作为各种疾病治疗剂的潜力,凸显了在该领域持续研究的重要性。
更新日期:2024-08-04
中文翻译:
食物来源的生物活性肽与肠道微生物群的相互作用:对健康和疾病管理的影响
生物活性肽 (BPs) 是对新陈代谢、生理和疾病有有益影响的蛋白质片段。本综述重点介绍蛋白水解 BPs,它是由肠道微生物群对食物中蛋白质的作用产生的,并已被证明会影响肠道微生物的组成。肠道菌群是 BP 的候选靶点,可缓解氧化应激、增强免疫力和控制疾病,包括糖尿病、高血压、肥胖、癌症以及免疫和神经退行性疾病。尽管取得了有希望的结果,但仍需要进一步的研究来了解 BPs 与肠道微生物之间相互作用的潜在机制,并识别和筛选更多用于工业应用的 BPs。总体而言,BP 通过与肠道微生物的相互作用提供了作为各种疾病治疗剂的潜力,凸显了在该领域持续研究的重要性。