A recent study in Nature Medicine describes a multi-parametric profile of a pre-metastatic signature using liver biopsy samples to predict metastatic outcomes in early-stage pancreatic cancer (PaC). The investigators obtained liver biopsy samples during pancreatectomy from patients with localized PaC (n = 49) and without cancerous lesions (n = 19).

The liver samples were analysed by combining imaging techniques with metabolomics and tissue and single-cell transcriptomics. Patients were followed up for a median of 3 years and were classified according to their metastatic status. The researchers identified features in the PaC livers to predict metastatic outcomes and distinguish patients who developed liver or extrahepatic metastasis from disease-free survivors. Those biomarkers included enrichment of neutrophil extracellular traps, T cell lobular infiltration, overexpression of interferon target genes and an increase of CD11B⁺ natural killer cells, among others.

《自然医学》上最近的一项研究描述了使用肝活检样本预测早期胰腺癌 （PaC） 转移前特征的多参数图谱。研究人员在胰腺切除术期间从局部 PaC （n = 49） 和无癌性病变 （n = 19） 的患者那里获得了肝活检样本。

通过将成像技术与代谢组学和组织和单细胞转录组学相结合来分析肝脏样本。患者中位随访 3 年，并根据其转移状态进行分类。研究人员确定了 PaC 肝脏的特征，以预测转移结果，并区分发生肝脏或肝外转移的患者与无病幸存者。这些生物标志物包括中性粒细胞胞外陷阱的富集、T 细胞小叶浸润、干扰素靶基因的过表达和 CD11B⁺ 自然杀伤细胞的增加等。