BackgroundWhile food allergy (FA) can be fatal, the greatest public health impact of FA arguably lies in its detrimental effect on quality of life (FAQOL). Understanding the factors that contribute to FAQOL at different ages is essential to develop personalized interventions that will improve FAQOL.ObjectiveTo determine the most influential factors that impact FAQOL across ages in well‐phenotyped participants with confirmed FA.MethodsOne hundred and twenty‐five individuals aged 2–28 years with IgE‐mediated FA completed validated age‐specific FAQOL questionnaires. The relationship between demographic/clinical variables and scores were analyzed to identify key predictors of FAQOL.ResultsPoor FAQOL was associated with increasing age, strict avoidance practices, reactions to trace exposures, and more severe reactions as assessed by epinephrine use, anaphylaxis, and/or treatment in the emergency department; FAQOL improved with time from the event. FAQOL was worse in subjects avoiding >2 versus ≤2 foods and in those avoiding milk, egg, soy, sesame, or wheat. Number of foods avoided had greatest impact on children ages 2–7 years, while total number of allergic reactions strongly impacted FAQOL in teens and adults; FAQOL of subjects ages 8–12 years appeared less affected by these variables compared to other age groups. A decision tree analysis identified key predictors of overall FAQOL (age, number of food avoidances, and time since epinephrine use) that can be used to guide intervention strategies to improve FAQOL.ConclusionWe directly compared FAQOL in extensively phenotyped children, teenagers, and adults with confirmed IgE‐mediated FA. Age; timing, number, and severity of reactions; type and number of FA; and food avoidance practices influence FAQOL and should guide intervention strategies.

中文翻译：

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影响 IgE 介导的食物过敏患者生活质量的关键因素因年龄而异


背景虽然食物过敏 (FA) 可能致命，但 FA 对公共健康的最大影响可以说在于其对生活质量 (FAQOL) 的有害影响。了解不同年龄阶段影响 FAQOL 的因素对于制定改善 FAQOL 的个性化干预措施至关重要。目的确定 FA 已证实的表型良好的参与者中影响各个年龄段 FAQOL 的最有影响力的因素。方法 125 名 2 岁个体– 28 岁，使用 IgE 介导的 FA 完成了经过验证的年龄特异性 FAQOL 问卷。分析人口/临床变量和分数之间的关系，以确定 FAQOL 的关键预测因素。 结果 较差的 FAQOL 与年龄增加、严格回避实践、对微量暴露的反应以及通过肾上腺素使用、过敏反应和/或评估的更严重反应有关。在急诊室接受治疗；随着活动的进行，FAQOL 不断得到改进。避免 >2 食物的受试者与避免 ≤2 种食物的受试者以及避免牛奶、鸡蛋、大豆、芝麻或小麦的受试者的 FAQOL 表现更差。避免的食物数量对 2-7 岁儿童影响最大，而过敏反应总数对青少年和成人的 FAQOL 影响很大；与其他年龄组相比，8-12 岁受试者的常见问题解答似乎受这些变量的影响较小。决策树分析确定了总体 FAQOL（年龄、避免食物的次数和使用肾上腺素后的时间）的关键预测因素，可用于指导改善 FAQOL 的干预策略。结论我们直接将广泛表型儿童、青少年和成人的 FAQOL 与证实了 IgE 介导的 FA。 年龄;反应的时间、数量和严重程度； FA 的类型和数量；避免食物的做法会影响常见问题解答并应指导干预策略。