Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives,Chemical Society Reviews

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Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-08-02 , DOI: 10.1039/d4cs00636d
Zhaoyou Chu _{1,

2} , Wanni Wang ₁ , Wang Zheng ₁ , Wanyue Fu ₁ , Yujie Wang ₁ , Hua Wang ₂ , Haisheng Qian _{1,

3}

Affiliation

Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment, etc. In the past few decades, nanostructure-mediated therapeutic strategies have been developed to improve drug delivery, targeted therapy, and diagnosis, maximizing therapeutic effectiveness while reducing systemic toxicity and side effects by exploiting the complicated interactions between the materials and the cell and tissue microenvironments. This review briefly introduces the differences between the cells and tissues of tumour or normal cells. We summarize recent advances in tumour microenvironment-mediated therapeutic strategies using nanostructured materials. We then comprehensively discuss strategies for fabricating nanostructures with cancer cell-specific cytotoxicity by precisely controlling their composition, particle size, shape, structure, surface functionalization, and external energy stimulation. Finally, we present perspectives on the challenges and future opportunities of nanotechnology-based toxicity strategies in tumour therapy.

中文翻译：

具有癌细胞特异性细胞毒性的生物材料：挑战和前景

生物医学应用材料取得了重大进展，包括组织工程、生物成像、癌症治疗等。在过去的几十年里，纳米结构介导的治疗策略已被开发出来，以改善药物输送、靶向治疗和诊断，最大限度地提高治疗效果同时通过利用材料与细胞和组织微环境之间复杂的相互作用来减少系统毒性和副作用。本文简要介绍肿瘤细胞和正常细胞的细胞和组织之间的差异。我们总结了使用纳米结构材料的肿瘤微环境介导的治疗策略的最新进展。然后，我们全面讨论通过精确控制纳米结构的成分、粒径、形状、结构、表面功能化和外部能量刺激来制造具有癌细胞特异性细胞毒性的纳米结构的策略。最后，我们对基于纳米技术的毒性策略在肿瘤治疗中的挑战和未来机遇提出了看法。

更新日期：2024-08-04

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