The arid region of Northwest China (ARNC) has experienced a significantly higher warming rate than the global average and exhibits pronounced seasonal asymmetry, which has important implications for the region’s water-dependent systems. To understand the spatiotemporal patterns and driving mechanisms of seasonal asymmetric warming in the ARNC, we investigated seasonal changes in temperature rise and their underlying causes based on station and reanalysis data. We found that the dominant season of temperature increase shifted from winter to spring. The contribution of spring warming to the total temperature increase rose from −5%–7% to 58%–59%, while the contribution of winter warming decreased from 60%–75% to −4%–9%. However, the mechanisms underlying spring warming and winter cooling differ. An increase in solar radiation caused by a decrease in cloud cover (R = −0.64) was the main reason for spring warming, while a strengthening Siberian High primarily drove winter cooling.