Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study.,The Journal of Urology

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Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study.
The Journal of Urology ( IF 5.9 ) Pub Date : 2024-08-02 , DOI: 10.1097/ju.0000000000004187
Anders Breinbjerg _{1,

2} , Cecilie Siggaard Jørgensen _{1,

2} , G Bragi Walters _{3,

4} , Jakob Grove _{5,

6,

7,

8,

9} , Thomas D Als _{5,

6,

7,

8} , Konstantinos Kamperis _{1,

2} , Lilja Stéfansdóttir ₃ , Janne P Thirstrup _{5,

6,

8} , Britt Borg _{1,

2} , Clara Albiñana ₁₀ , Bjarni J Vilhjálmsson _{5,

9,

10,

11} , Viðar Ö Eðvarðsson _{4,

12} , Hreinn Stefánsson ₃ , Preben B Mortensen _{5,

10,

13} , Esben Agerbo _{5,

10,

13} , Thomas Werge _{5,

14,

15} , Anders Børglum _{5,

6,

7,

8} , Ditte Demontis _{5,

6,

8,

11} , Kári Stefánsson _{3,

4} , Søren Rittig _{1,

2} , Jane Hvarregaard Christensen _{5,

6,

7,

8}

Affiliation

Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
deCODE genetics/Amgen, Reykjavík, Iceland.
Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen and Aarhus, Denmark.
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
Centre for Genomics and Personalized Medicine, CGPM, Aarhus University, Aarhus, Denmark.
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
NCRR - National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Children's Medical Center, Landspitali-The National University Hospital of Iceland, Reykjavík, Iceland.
CIRRAU-Center for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Childhood incontinence is stigmatized and underprioritized, and a basic understanding of its pathogenesis is missing. Our goal was to identify risk-conferring genetic variants in daytime urinary incontinence (DUI).

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