ObjectivesThe aim of this study was to evaluate the systemic effect of non‐surgical peri‐implantitis treatment (NSPIT) with or without the administration of systemic metronidazole.MethodsIn this secondary analysis from a previously published clinical trial (NCT03564301), peri‐implantitis patients were randomized into two groups: test, receiving NSPIT plus 500 mg of oral systemic metronidazole three times a day for 7 days (n = 10); and control group, receiving NSPIT plus placebo (n = 11). Serum samples were obtained at baseline, 3 and 6 months after therapy to determine levels of inflammatory biomarkers, lipid fractions and complete blood counts.ResultsBoth treatment modalities produced improvements in clinical and radiographic parameters. After 6 months from NSPIT, a substantial reduction in C‐reactive protein (6.9 mg/dL; 95% CI: 3.7 to 9.9, p < .001) and low‐density lipoprotein cholesterol (21.8 mg/dL; 95% CI: −6.9 to 50.5, p = .013) as well as a modest increase in neutrophils counts (0.4 × 103/μL; 95% CI: −0.4 to 1.1, p = .010) was observed in the control group while the test group showed a significant reduction of TNF‐α (110.1; 95% CI: 38.9 to 181.4, p = .004).ConclusionsNSPIT showed a short‐term beneficial systemic effect regardless of adjunctive use of systemic metronidazole.

中文翻译：

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种植体周围炎非手术治疗伴或不伴辅助全身性甲硝唑的全身影响：一项随机临床试验的二次分析


目的本研究的目的是评估非手术种植体周围炎治疗 （NSPIT） 联合或不联合全身性甲硝唑的全身效应。方法在先前发表的临床试验 （NCT03564301） 的二次分析中，种植体周围炎患者被随机分为两组：测试，接受 NSPIT 加 500 mg 口服全身性甲硝唑，每天 3 次，持续 7 天 （n = 10）;对照组，接受 NSPIT 加安慰剂 （n = 11）。在基线、治疗后 3 个月和 6 个月采集血清样本，以确定炎症生物标志物、血脂分数和全血细胞计数的水平。结果两种治疗方式均改善了临床和影像学参数。NSPIT 治疗 6 个月后，对照组观察到 C 反应蛋白（6.9 mg/dL;95% CI：3.7 至 9.9，p < .001）和低密度脂蛋白胆固醇（21.8 mg/dL;95% CI：-6.9 至 50.5，p = .013）以及中性粒细胞计数适度增加（0.4 × 103/μL;95% CI：-0.4 至 1.1，p = .010），而试验组显示 TNF-α 显著降低（110.1;95% CI：38.9 至 181.4，p = .004）。结论NSPIT 显示出短期有益的全身效应，无论是否辅助使用全身性甲硝唑。