ObjectivesThe aim of this study was to evaluate the systemic effect of non‐surgical peri‐implantitis treatment (NSPIT) with or without the administration of systemic metronidazole.MethodsIn this secondary analysis from a previously published clinical trial (NCT03564301), peri‐implantitis patients were randomized into two groups: test, receiving NSPIT plus 500 mg of oral systemic metronidazole three times a day for 7 days (n = 10); and control group, receiving NSPIT plus placebo (n = 11). Serum samples were obtained at baseline, 3 and 6 months after therapy to determine levels of inflammatory biomarkers, lipid fractions and complete blood counts.ResultsBoth treatment modalities produced improvements in clinical and radiographic parameters. After 6 months from NSPIT, a substantial reduction in C‐reactive protein (6.9 mg/dL; 95% CI: 3.7 to 9.9, p < .001) and low‐density lipoprotein cholesterol (21.8 mg/dL; 95% CI: −6.9 to 50.5, p = .013) as well as a modest increase in neutrophils counts (0.4 × 103/μL; 95% CI: −0.4 to 1.1, p = .010) was observed in the control group while the test group showed a significant reduction of TNF‐α (110.1; 95% CI: 38.9 to 181.4, p = .004).ConclusionsNSPIT showed a short‐term beneficial systemic effect regardless of adjunctive use of systemic metronidazole.

中文翻译：

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非手术治疗种植体周围炎联合或不联合辅助全身甲硝唑的全身影响：随机临床试验的二次分析


目的 本研究的目的是评估非手术种植体周围炎治疗 (NSPIT) 的全身效果，无论是否全身使用甲硝唑。方法在先前发表的临床试验 (NCT03564301) 的二次分析中，种植体周围炎患者随机分为两组：测试，接受 NSPIT 加 500 mg 口服全身甲硝唑，每天 3 次，持续 7 天（ n = 10);对照组接受 NSPIT 加安慰剂（ n = 11）。在基线、治疗后 3 个月和 6 个月时采集血清样本，以确定炎症生物标志物、脂质分数和全血细胞计数的水平。结果两种治疗方式均改善了临床和放射学参数。 NSPIT 6 个月后，C 反应蛋白大幅降低（6.9 mg/dL；95% CI：3.7 至 9.9， p < .001）和低密度脂蛋白胆固醇（21.8 mg/dL；95% CI：-6.9 至 50.5， p = .013) 以及中性粒细胞计数适度增加 (0.4 × 10 3 /μL； 95% CI：-0.4 至 1.1， p = .010）在对照组中观察到，而测试组则显示 TNF-α 显着减少（110.1；95% CI：38.9 至 181.4， p = .004)。结论 无论是否辅助使用全身甲硝唑，NSPIT 都显示出短期有益的全身效应。