Aqueous Extract of Wolfberry Alleviates Aging-Related Skeletal Muscle Dysfunction by Modulating PRRs Signaling Pathways and Enhancing DNA Repair,Molecular Nutrition & Food Research

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Aqueous Extract of Wolfberry Alleviates Aging-Related Skeletal Muscle Dysfunction by Modulating PRRs Signaling Pathways and Enhancing DNA Repair
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-01 , DOI: 10.1002/mnfr.202400307
Qingwei Zheng ₁ , Xiaofang Chen ₂ , Waleed Al-Ansi ₁ , Mingcong Fan ₁ , Haifeng Qian ₁ , Li Wang ₁ , Yan Li ₁

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Aging can lead to a series of degenerative changes in skeletal muscle, which would negatively impact physical activity and the quality of life of the elderly. Wolfberry contains numerous bioactive substances. It's vital to further explore the mechanisms underlying its healthy effects on skeletal muscle function during aging progress. This study discusses the benefits and mechanisms of aqueous extract of wolfberry (AEW) to protect skeletal muscle from aging-related persistent DNA damage based on its anti-inflammatory activity. It is found that AEW improves muscle mass, strength, and endurance, modulates the expression of Atrogin-1, MyH, and MuRF-1, and decreases oxidative stress and inflammation levels in aging mice, which is consistent with the in vitro results. Mechanistically, AEW inhibits the pattern recognition receptors (PRRs) pathway induced by inflammatory gene activation, suggesting its potential in response to DNA damage. AEW is also observed to mitigate chromatin decompaction. Network pharmacology is conducted to analyze the potential targets of AEW in promoting DNA repair. In conclusion, the study shows the anti-aging effects of AEW on skeletal muscle by promoting DNA repair and reducing the transcriptional activity of inflammatory factors. AEW intake may become a potential strategy for strengthening skeletal muscle function in the elderly.

中文翻译：

枸杞水提取物通过调节 PRRs 信号通路和增强 DNA 修复来缓解与衰老相关的骨骼肌功能障碍

衰老会导致骨骼肌发生一系列退行性变化，从而对老年人的体育活动和生活质量产生负面影响。枸杞含有多种生物活性物质。进一步探索其在衰老过程中对骨骼肌功能健康影响的潜在机制至关重要。本研究讨论了枸杞水提取物（AEW）基于其抗炎活性保护骨骼肌免受与衰老相关的持续 DNA 损伤的好处和机制。研究发现，AEW 可改善肌肉质量、力量和耐力，调节 Atrogin-1、MyH 和 MuRF-1 的表达，并降低衰老小鼠的氧化应激和炎症水平，这与体外结果一致。从机制上讲，AEW 抑制炎症基因激活诱导的模式识别受体（PRR）通路，表明其响应 DNA 损伤的潜力。还观察到 AEW 可以减轻染色质压缩。进行网络药理学分析AEW促进DNA修复的潜在靶点。总之，该研究表明 AEW 通过促进 DNA 修复和降低炎症因子的转录活性对骨骼肌的抗衰老作用。AEW 摄入量可能成为增强老年人骨骼肌功能的潜在策略。

更新日期：2024-08-01

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