Midgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumors and the unexplained occurrence of multifocal tumors makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the understanding of the interplay of the genetic, epigenetic, and transcriptomic landscape in the development of midgut NENs, a topic that is critical to understanding their biology and improving treatment options and outcomes for patients.

中文翻译：

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中肠神经内分泌肿瘤的分子生物学。


中肠神经内分泌肿瘤（NEN）是 NEN 最常见的亚型之一，其发病率在全球范围内呈上升趋势。尽管是最常诊断出的小肠恶性肿瘤，但对其潜在的分子生物学知之甚少。与其他实体瘤相比，它们的突变负担异常低，并且多灶性肿瘤的发生无法解释，使得中肠 NEN 的分子生物学成为一个特别令人着迷的研究领域。这篇综述概述了中肠 NEN 发育过程中遗传、表观遗传和转录组学相互作用的最新进展，这一主题对于理解其生物学以及改善患者的治疗选择和结果至关重要。