Environmental or occupational exposure to natural uranium can have adverse health effects, with its chemical toxicity being mainly directed towards the kidneys and skeleton. This has led to the development of chelating agents to remove uranium from the human body, including the ligand 3,4,3-LI(1,2-HOPO). We have developed a new assay to assess the efficacy of 3,4,3-LI(1,2-HOPO) in attenuating uranium-induced bone cell damage. This approach uses osteoclasts whose formation and function are altered by exposure to uranium. This assay is an interesting and effective alternative to animal methods for assessing the efficacy and safety of new uranium decorporants.

中文翻译：

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一种新的体外铀封存测定，用于分析 3,4,3-LI(1,2-HOPO) 在减少该锕系元素对骨细胞有害影响方面的有效性


环境或职业接触天然铀会对健康产生不利影响，其化学毒性主要针对肾脏和骨骼。这导致了螯合剂的开发，以去除人体内的铀，包括配体 3,4,3-LI(1,2-HOPO)。我们开发了一种新的检测方法来评估 3,4,3-LI(1,2-HOPO) 在减轻铀引起的骨细胞损伤方面的功效。这种方法使用破骨细胞，其形成和功能会因暴露于铀而改变。该测定是动物方法的一种有趣且有效的替代方法，用于评估新型铀装饰剂的功效和安全性。