A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia,Journal of Advanced Research

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A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2024-07-25 , DOI: 10.1016/j.jare.2024.07.020
Xuequan Liu ₁ , Xuequan Sun ₂ , Hongyu Zhu ₃ , Rubing Yan ₄ , Chang Xu ₂ , Fangxing Zhu ₂ , Ruijie Xu ₅ , Jing Xia ₃ , He Dong ₃ , Bingcheng Yi ₆ , Qihui Zhou ₆

Affiliation

Introduction

One of the methods for pain management involves the use of local anesthesia, which numbs sensations in specific body regions while maintaining consciousness.

Objectives

Considering the certain limitations (e.g., pain, the requirement of skilled professionals, or slow passive diffusion) of conventional delivery methods of local anesthetics, developing alternative strategies that offer minimally invasive yet therapeutically effective delivery systems is of great concern for ophthalmic regional anesthesia.

Methods and results

In this study, a rapidly dissolving cambered microneedle (MNs) patch, composed of poly(vinylpyrrolidone) (PVP) and hyaluronic acid (HA) and served as a delivery system for lidocaine (Lido) in local anesthesia, was developed taking inspiration from the mosquito proboscis’s ability to extract blood unnoticed. The lidocaine-containing MNs patch (MNs@Lido) consisted of 25 microneedles with a four-pronged cone structure (height: 500 μm, base width: 275 μm), arranged in a concentric circle pattern on the patch, and displays excellent dissolubility for effective drug delivery of Lido. After confirming good cytocompatibility, MNs@Lido was found to possess adequate rigidity to penetrate the cornea without causing any subsequent injury, and the created corneal pinhole channels completely self-healed within 24 h. Interestingly, MNs@Lido exhibited effective analgesic effects for local anesthesia on both heel skin and eyeball, with the sustained anesthetic effect lasting for at least 30 min.

Conclusions

These findings indicate that the mosquito proboscis-inspired cambered MNs patch provides rapid and painless local anesthesia, overcoming the limitations of conventional delivery methods of local anesthetics, thus opening up new possibilities in the treatment of ophthalmic diseases.

中文翻译：

一种用于眼部区域麻醉的蚊子长鼻式弧形微针贴剂

介绍

疼痛管理的方法之一涉及使用局部麻醉，在保持意识的同时麻痹特定身体区域的感觉。

目标

考虑到局部麻醉剂传统输送方法的某些局限性（例如，疼痛、需要熟练的专业人员或缓慢的被动扩散），开发提供微创但治疗有效的输送系统的替代策略是眼科区域麻醉非常关注的问题。

方法和结果

在这项研究中，开发了一种快速溶解的弧形微针（MNs）贴片，由聚乙烯吡咯烷酮（PVP）和透明质酸（HA）组成，并在局部麻醉中用作利多卡因（Lido）的输送系统，其灵感来自蚊子长鼻在不被注意的情况下抽血的能力。含利多卡因的 MNs 贴剂（MNs@Lido）由 25 个具有四叉锥形结构（高：500 μm，基宽：275 μm）的微针组成，在贴剂上呈同心圆排列，表现出优异的溶解性，可有效递送 Lido。在确认良好的细胞相容性后，发现MNs@Lido具有足够的刚度，可以穿透角膜而不会造成任何后续损伤，并且创建的角膜针孔通道在 24 小时内完全自愈。有趣的是，MNs@Lido 对足跟皮肤和眼球的局部麻醉均表现出有效的镇痛作用，持续麻醉效果持续至少 30 分钟。