2-Year Outcomes of an Atrial Shunt Device in HFpEF/HFmrEF: Results From REDUCE LAP-HF II,JACC: Heart Failure

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2-Year Outcomes of an Atrial Shunt Device in HFpEF/HFmrEF: Results From REDUCE LAP-HF II
JACC: Heart Failure ( IF 10.3 ) Pub Date : 2024-06-26 , DOI: 10.1016/j.jchf.2024.04.011
Finn Gustafsson ₁ , Mark C Petrie ₂ , Jan Komtebedde ₃ , Vijendra Swarup ₄ , Sebastian Winkler ₅ , Gerd Hasenfuß ₆ , Barry A Borlaug ₇ , Rajeev C Mohan ₈ , James D Flaherty ₉ , Aaron L Sverdlov ₁₀ , Peter S Fail ₁₁ , Eugene S Chung ₁₂ , Philipp Lurz ₁₃ , Scott Lilly ₁₄ , David M Kaye ₁₅ , John G F Cleland ₂ , Maja Cikes ₁₆ , Martin B Leon ₁₇ , Donald E Cutlip ₁₈ , Dirk J van Veldhuisen ₁₉ , Scott D Solomon ₂₀ , Sanjiv J Shah ₉

Affiliation

Rigshospitalet, University of Copenhagen, Denmark.
British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.
Corvia Medical, Inc, Tewksbury, Massachusetts, USA.
Arizona Heart and Rhythm Center, Phoenix, Arizona, USA.
B.G. Klinikum Unfallkrankenhaus, Berlin, Germany.
Heart Center, University Medical Center, Göttingen, Germany.
Mayo Clinic, Rochester, Minnesota, USA.
Scripps Health, La Jolla, California, USA.
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
John Hunter Hospital, University of Newcastle, New Lambton Heights, Australia.
Cardiovascular Institute of the South, Houma, Louisiana, USA.
The Lindner Research Center at The Christ Hospital, Cincinnati, Ohio, USA.
Cardiology Center, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Ohio State University, Columbus, Ohio, USA.
Alfred Hospital, Melbourne, Australia.
University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.
Cardiovascular Research Foundation, New York, New York, USA.
Baim Clinical Research Institute, Boston, Massachusetts, USA.
University Medical Center Groningen, Groningen, the Netherlands.
Brigham and Women's Hospital, Boston, Massachusetts, USA.

The REDUCE LAP-HF II (Reduce Elevated Left Atrial Pressure in Patients With Heart Failure II) trial found that, compared with a sham procedure, the Corvia Atrial Shunt did not improve outcomes in heart failure with preserved or mildly reduced ejection fraction. However, after 12-month follow-up, “responders” (peak-exercise pulmonary vascular resistance <1.74 WU and absence of a cardiac rhythm management device) were identified.

中文翻译：

心房分流装置治疗 HFpEF/HFmrEF 的 2 年结果：REDUCE LAP-HF II 的结果

REDUCE LAP-HF II（降低心力衰竭患者左心房压力升高 II）试验发现，与假手术相比，Corvia 心房分流术并没有改善射血分数保留或轻度降低的心力衰竭患者的结局。然而，经过 12 个月的随访后，确定了“反应者”（峰值运动肺血管阻力 <1.74 WU 且没有心律管理装置）。

更新日期：2024-06-26

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