The study of small, regulatory RNAs (sRNA) that act by base-pairing with target RNAs in bacteria has been steadily advancing, particularly with the availability of more and more transcriptome and RNA-RNA interactome datasets. While the characterization of multiple sRNAs has helped to elucidate their mechanisms of action, these studies also are providing insights into protein function, control of metabolic flux, and connections between metabolic pathways as we will discuss here. In describing several examples of the metabolic insights gained, we will summarize the different types of base-pairing sRNAs including mRNA-derived sRNAs, sponge RNAs, RNA mimics, and dual-function RNAs as well as suggest how information about sRNAs could be exploited in the future.

中文翻译：

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从小 RNA 深入了解细菌代谢


通过与细菌中的靶 RNA 碱基配对发挥作用的小调节 RNA (sRNA) 的研究一直在稳步推进，特别是随着越来越多的转录组和 RNA-RNA 相互作用数据集的出现。虽然多种 sRNA 的表征有助于阐明它们的作用机制，但这些研究也提供了对蛋白质功能、代谢流控制以及代谢途径之间联系的见解，我们将在此讨论。在描述所获得的代谢见解的几个例子时，我们将总结不同类型的碱基配对 sRNA，包括 mRNA 衍生的 sRNA、海绵 RNA、RNA 模拟物和双功能 RNA，并建议如何在研究中利用有关 sRNA 的信息。未来。