We have developed a versatile approach for promoting the penetration of commensal bacteria into the intestinal mucosa, by coating the bacterial surface with poly(ethylene glycol) (PEG). PEGylation-enabled penetration facilitated the preferential localization of bacteria at the mucus layer of the intestinal mucosal barrier, thereby reinforcing this barrier.

中文翻译：

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聚乙二醇化细菌穿透粘液并增强肠道粘膜屏障


我们开发了一种通用方法，通过用聚乙二醇 (PEG) 涂覆细菌表面来促进共生细菌渗透到肠粘膜中。聚乙二醇化的渗透促进了细菌在肠粘膜屏障的粘液层的优先定位，从而增强了该屏障。