Acute kidney injury (AKI) is a common complication that occurs in approximately 20% of hospitalized patients. Clinical and preclinical studies have revealed that AKI is a complex systemic disease affecting every organ. Addressing these systemic complications is essential to reduce AKI mortality. However, the effects of AKI on the liver, another major metabolic organ, are still unknown. A study in Scientific Reports characterizes the hepatic metabolome in male C57BL/6 after ischemic AKI. 24 hours after AKI, mice showed severe depletion of antioxidants and ATP levels compared with sham animals. Remarkably, although inflammation and oxidative stress are usually associated, there was no difference in inflammation between AKI and sham mice. While, both energetic and oxidative stress markers were affected, no liver damage or decrease in energy production were observed, suggesting an overall increase in consumption of metabolites. These results highlight the AKI-related kidney-liver crosstalk and provide additional insights into the complex systemic nature of AKI in general.

Original reference: Baker, P.R. 2nd et al. Sci. Rep. 14, 13862 (2024)

急性肾损伤 (AKI) 是一种常见并发症，约 20% 的住院患者会发生这种情况。临床和临床前研究表明，AKI 是一种影响每个器官的复杂系统性疾病。解决这些全身并发症对于降低 AKI 死亡率至关重要。然而，AKI 对另一个主要代谢器官肝脏的影响仍不清楚。 《科学报告》中的一项研究描述了男性 C57BL/6 缺血性 AKI 后肝脏代谢组的特征。 AKI 后 24 小时，与假手术动物相比，小鼠的抗氧化剂和 ATP 水平严重消耗。值得注意的是，尽管炎症和氧化应激通常相关，但 AKI 小鼠和假小鼠之间的炎症没有差异。虽然能量和氧化应激标记物均受到影响，但没有观察到肝损伤或能量产生减少，表明代谢物消耗总体增加。这些结果强调了 AKI 相关的肾-肝串扰，并为总体上 AKI 的复杂系统性质提供了更多见解。

原始参考文献： Baker, PR 2nd et al.科学。代表。 14、13862 (2024)