Acute kidney injury (AKI) is a common complication that occurs in approximately 20% of hospitalized patients. Clinical and preclinical studies have revealed that AKI is a complex systemic disease affecting every organ. Addressing these systemic complications is essential to reduce AKI mortality. However, the effects of AKI on the liver, another major metabolic organ, are still unknown. A study in Scientific Reports characterizes the hepatic metabolome in male C57BL/6 after ischemic AKI. 24 hours after AKI, mice showed severe depletion of antioxidants and ATP levels compared with sham animals. Remarkably, although inflammation and oxidative stress are usually associated, there was no difference in inflammation between AKI and sham mice. While, both energetic and oxidative stress markers were affected, no liver damage or decrease in energy production were observed, suggesting an overall increase in consumption of metabolites. These results highlight the AKI-related kidney-liver crosstalk and provide additional insights into the complex systemic nature of AKI in general.

Original reference: Baker, P.R. 2nd et al. Sci. Rep. 14, 13862 (2024)

急性肾损伤 （AKI） 是一种常见并发症，发生在大约 20% 的住院患者中。临床和临床前研究表明，AKI 是一种影响每个器官的复杂全身性疾病。解决这些全身并发症对于降低 AKI 死亡率至关重要。然而，AKI 对肝脏（另一个主要代谢器官）的影响仍然未知。Scientific Reports 上的一项研究表征了缺血性 AKI 后男性 C57BL/6 的肝脏代谢组。AKI 后 24 小时，与假动物相比，小鼠表现出抗氧化剂和 ATP 水平的严重消耗。值得注意的是，尽管炎症和氧化应激通常相关，但 AKI 和假小鼠之间的炎症没有差异。虽然能量和氧化应激标志物都受到影响，但没有观察到肝损伤或能量产生减少，这表明代谢物的消耗总体增加。这些结果突出了 AKI 相关的肾肝串扰，并为 AKI 的一般复杂性系统性质提供了更多见解。

原始参考资料：Baker， P.R. 2nd et al. Sci. Rep.14， 13862 （2024）