<br>发病机制相关蛋白的双重功能：植物中的防御作用与病原体中的免疫抑制作用,Frontiers in Plant Science

当前位置： X-MOL 学术 › Front. Plant Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

发病机制相关蛋白的双重功能：植物中的防御作用与病原体中的免疫抑制作用
Frontiers in Plant Science ( IF 4.1 ) Pub Date : 2024-08-02 , DOI: 10.3389/fpls.2024.1368467
Zhu Han ₁ , Roger Schneiter ₁

Affiliation

植物通过激活一组防御相关蛋白（称为发病机制相关 (PR) 蛋白）的表达来应对病原体暴露，这些蛋白最初于 20 世纪 70 年代发现。这些 PR 蛋白分为 17 个不同的家族，表示为 PR1-PR17。大多数这些蛋白质主要是分泌的，在质外体空间内发挥其防御作用。几种 PR 蛋白具有明确的酶功能，例如 β-葡聚糖酶 (PR2)、几丁质酶 (PR3、4、8、11)、蛋白酶 (PR7) 或 RNase (PR10)。 PR 蛋白过度表达可增强对病原体的抵抗力，而其下调则使植物更容易受到病原体感染。许多这些蛋白质表现出抗菌活性体外，并且由于其紧凑的尺寸，一些被归类为抗菌肽。最近的研究表明，包括线虫、真菌和疫霉在内的植物病原体利用类似的蛋白质来增强其毒力并抑制植物免疫力。这就提出了一个基本问题：这些保守蛋白如何在宿主植物产生时充当抗菌剂，同时在病原体产生时抑制植物免疫力？在这个假设中，我们研究了病原体产生的 PR 蛋白（我们称之为“PR 样蛋白”），并探索了此类毒力因子发挥作用的潜在机制。初步数据表明，这些蛋白质可能与宿主自身的 PR 蛋白质形成复合物，从而干扰其防御相关功能。这项分析揭示了植物和病原体衍生的 PR 样蛋白之间有趣的相互作用，为控制植物与病原体相互作用的复杂机制提供了新的见解。

"点击查看英文标题和摘要"

Dual functionality of pathogenesis-related proteins: defensive role in plants versus immunosuppressive role in pathogens

Plants respond to pathogen exposure by activating the expression of a group of defense-related proteins known as Pathogenesis-Related (PR) proteins, initially discovered in the 1970s. These PR proteins are categorized into 17 distinct families, denoted as PR1-PR17. Predominantly secreted, most of these proteins execute their defensive roles within the apoplastic space. Several PR proteins possess well-defined enzymatic functions, such as β-glucanase (PR2), chitinases (PR3, 4, 8, 11), proteinase (PR7), or RNase (PR10). Enhanced resistance against pathogens is observed upon PR protein overexpression, while their downregulation renders plants more susceptible to pathogen infections. Many of these proteins exhibit antimicrobial activity in vitro, and due to their compact size, some are classified as antimicrobial peptides. Recent research has unveiled that phytopathogens, including nematodes, fungi, and phytophthora, employ analogous proteins to bolster their virulence and suppress plant immunity. This raises a fundamental question: how can these conserved proteins act as antimicrobial agents when produced by the host plant but simultaneously suppress plant immunity when generated by the pathogen? In this hypothesis, we investigate PR proteins produced by pathogens, which we term “PR-like proteins,” and explore potential mechanisms by which this class of virulence factors operate. Preliminary data suggests that these proteins may form complexes with the host’s own PR proteins, thereby interfering with their defense-related functions. This analysis sheds light on the intriguing interplay between plant and pathogen-derived PR-like proteins, providing fresh insights into the intricate mechanisms governing plant-pathogen interactions.

更新日期：2024-08-02

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南