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All-Cause Mortality and Cause-Specific Death in U.S. Long-Lived Siblings: Data From the Long Life Family Study
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 4.3 ) Pub Date : 2024-07-31 , DOI: 10.1093/gerona/glae190
Shanshan Yao 1 , Robert M Boudreau 1 , Angéline Galvin 2 , Joanne M Murabito 3 , Lawrence S Honig 4 , Thomas T Perls 5 , Kaare Christensen 2 , Anne B Newman 1
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Background This study compared the mortality risk of long-lived siblings with the U.S. population average and their spouse controls, and investigated the leading causes of death and the familial effect in death pattern. Methods In the Long Life Family Study (LLFS), 1 264 proband siblings (mean age 90.1, standard deviation [SD] 6.4) and 172 spouses (83.8, 7.2) from 511 U.S.-based families were recruited and followed more than 12 years. Their survival function was compared with a birth cohort-, baseline age-, sex-, and race-matched pseudo sample from U.S. census data. To examine underlying and contributing causes, we examined in detail 338 deaths with complete death adjudication at the University of Pittsburgh Field Center through the year 2018. A familial effect on survival and death patterns was examined using mixed-effect models. Results The LLFS siblings had better survival than the matched U.S. population average. They also had slightly but not significantly better survival than their spouses’ (HR = 1.18 [95%CI 0.94–1.49]) after adjusting for age and sex. Age at death ranged from 75 to 104 years, mean 91.4. The leading causes of death were cardiovascular disease (33.1%), dementia (22.2%), and cancer (10.7%). Mixed effect model shows a significant random effect of family in survival, with adjustment of baseline age and sex. There was no significant familial effect in the underlying cause of death or conditions directly contributing to death among siblings recruited by the University of Pittsburgh Field Center. Conclusions Our findings demonstrate a higher survival in the LLFS siblings than the U.S. census data, with a familial component of survival. We did not find significant correspondence in causes of death between siblings within families.

中文翻译:


美国长寿兄弟姐妹的全因死亡率和特定原因死亡:来自长寿家庭研究的数据



背景 本研究将长寿兄弟姐妹的死亡风险与美国人口平均水平及其配偶对照进行了比较,并调查了死亡模式的主要原因和家族效应。方法 在长寿家庭研究 (LLFS) 中,招募了来自 511 个美国家庭的 1 264 名先证者兄弟姐妹 (平均年龄 90.1,标准差 [SD] 6.4) 和 172 名配偶 (83.8,7.2) 并随访超过 12 年。将他们的生存功能与来自美国人口普查数据的出生队列、基线年龄、性别和种族匹配的伪样本进行比较。为了检查根本原因和促成原因,我们详细检查了 338 年匹兹堡大学现场中心的 2018 例死亡和完全死亡裁决。使用混合效应模型检查了家族对生存和死亡模式的影响。结果 LLFS 兄弟姐妹的存活率高于匹配的美国种群平均水平。在调整年龄和性别后,他们的生存率也略高于配偶 (HR = 1.18 [95% CI 0.94–1.49]),但没有显著改善。死亡年龄从 75 岁到 104 岁不等,平均 91.4 岁。主要死亡原因是心血管疾病(33.1%)、痴呆(22.2%)和癌症(10.7%)。混合效应模型显示家庭在生存中具有显著的随机效应,基线年龄和性别的调整。在匹兹堡大学野外中心招募的兄弟姐妹中,潜在死亡原因或直接导致死亡的疾病没有显著的家族效应。结论 我们的研究结果表明,LLFS 兄弟姐妹的存活率高于美国人口普查数据,存活率具有家族成分。我们没有发现家庭内兄弟姐妹之间的死因存在显著的对应关系。
更新日期:2024-07-31
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